Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

• Zhang Q St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Bastard P Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Liu Z St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Le Pen J Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
• Moncada-Velez M St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Chen J St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Ogishi M St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Sabli IKD Department of Paediatric Infectious Diseases & Virology, Imperial College London, London, UK.
• Hodeib S Department of Paediatric Infectious Diseases & Virology, Imperial College London, London, UK.
• Korol C Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Rosain J Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Bilguvar K Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
• Ye J Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
• Bolze A Helix, San Mateo, CA, USA.
• Bigio B St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Yang R St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Arias AA St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Zhou Q St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Zhang Y Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
• Onodi F Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, Paris, France.
• Korniotis S Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, Paris, France.
• Karpf L Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, Paris, France.
• Philippot Q Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Chbihi M Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Bonnet-Madin L Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France.
• Dorgham K Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses-Paris (CIMI PARIS), Assistance Publique-Hôpitaux de Paris (AP-HP) Hôpital Pitié-Salpêtrière, Paris, France.
• Smith N Translational Immunology Lab, Institut Pasteur, Paris, France.
• Schneider WM Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
• Razooky BS Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
• Hoffmann HH Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
• Michailidis E Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
• Moens L Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
• Han JE St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Lorenzo L Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Bizien L Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Meade P Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• Neehus AL Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Ugurbil AC St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Corneau A Sorbonne Université, UMS037, PASS, Plateforme de Cytométrie de la Pitié-Salpêtrière CyPS, Paris, France.
• Kerner G Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Zhang P St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Rapaport F St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Seeleuthner Y Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Manry J Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Masson C Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France.
• Schmitt Y Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France.
• Schlüter A Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain.
• Le Voyer T Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• Khan T Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar.
• Li J St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Fellay J School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
• Roussel L Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montréal, Québec, Canada.
• Shahrooei M Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran.
• Alosaimi MF Department of Pathology and Laboratory Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
• Mansouri D Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
• Al-Saud H National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
• Al-Mulla F Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait.
• Almourfi F National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
• Al-Muhsen SZ Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
• Alsohime F Department of Pathology and Laboratory Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
• Al Turki S Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard Health Affairs, Riyadh, Saudi Arabia.
• Hasanato R Department of Pathology and Laboratory Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
• van de Beek D Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands.
• Biondi A Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.
• Bettini LR Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.
• D'Angio' M Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.
• Bonfanti P Department of Infectious Diseases, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy.
• Imberti L CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy.
• Sottini A CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy.
• Paghera S CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy.
• Quiros-Roldan E Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy.
• Rossi C Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy.
• Oler AJ Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.
• Tompkins MF PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
• Alba C PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
• Vandernoot I Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
• Goffard JC Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
• Smits G Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
• Migeotte I Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
• Haerynck F Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.
• Soler-Palacin P Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.
• Martin-Nalda A Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.
• Colobran R Immunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, UAB, Barcelona, Catalonia, Spain.
• Morange PE Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France.
• Keles S Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey.
• Çölkesen F Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey.
• Ozcelik T Department of Molecular Biology and Genetics, Bilkent University, Bilkent-Ankara, Turkey.
• Yasar KK Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
• Senoglu S Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
• Karabela ŞN Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
• Rodríguez-Gallego C Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain.
• Novelli G Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, Italy.
• Hraiech S Intensive Care Unit, AP-HM, Marseille, France.
• Tandjaoui-Lambiotte Y Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France.
• Duval X Université de Paris, IAME UMR-S 1137, INSERM, Paris, France.
• Laouénan C Université de Paris, IAME UMR-S 1137, INSERM, Paris, France.
• Snow AL St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Dalgard CL St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Milner JD St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Vinh DC St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Mogensen TH Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
• Marr N Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
• Spaan AN Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, Paris, France.
• Boisson B Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France.
• Boisson-Dupuis S Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.
• Bustamante J Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• Puel A Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• Ciancanelli MJ Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain.
• Meyts I Translational Immunology Lab, Institut Pasteur, Paris, France.
• Maniatis T Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA.
• Soumelis V St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Amara A Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses-Paris (CIMI PARIS), Assistance Publique-Hôpitaux de Paris (AP-HP) Hôpital Pitié-Salpêtrière, Paris, France.
• Nussenzweig M St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• García-Sastre A St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Krammer F Department of Paediatric Infectious Diseases & Virology, Imperial College London, London, UK.
• Pujol A Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
• Duffy D St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Lifton RP Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
• Zhang SY St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• Gorochov G Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
• Béziat V St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. casanova@rockefeller.edu.
• Jouanguy E
• Sancho-Shimizu V
• Rice CM
• Abel L
• Notarangelo LD
• Cobat A
• Su HC
• Casanova JL

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Adolescent

Adult

Aged

Aged, 80 and over

Alleles

Asymptomatic Infections

Betacoronavirus

Child

Child, Preschool

Coronavirus Infections

Female

Genetic Loci

Genetic Predisposition to Disease

Humans

Infant

Interferon Regulatory Factor-7

Interferon Type I

Loss of Function Mutation

Male

Middle Aged

Pandemics

Pneumonia, Viral

Receptor, Interferon alpha-beta

Toll-Like Receptor 3

Young Adult