A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
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Sung YJ
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yunju@wustl.edu.
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Winkler TW
Department of Genetic Epidemiology, University of Regensburg, Regensburg 93051, Germany.
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de Las Fuentes L
Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO 63110, USA.
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Bentley AR
Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
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Brown MR
Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA.
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Kraja AT
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Schwander K
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Ntalla I
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK.
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Guo X
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Franceschini N
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
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Lu Y
Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA.
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Cheng CY
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore.
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Sim X
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore.
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Vojinovic D
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Marten J
Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
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Musani SK
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA.
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Li C
Department of Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, GA 30602, USA.
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Feitosa MF
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Kilpeläinen TO
Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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Richard MA
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
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Noordam R
Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300RC, the Netherlands.
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Aslibekyan S
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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Aschard H
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Centre de Bioinformatique Biostatistique et Biologie Integrative (C3BI), Institut Pasteur, Paris 75015, France.
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Bartz TM
Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98101, USA.
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Dorajoo R
Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore.
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Liu Y
Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Manning AK
Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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Rankinen T
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
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Smith AV
Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
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Tajuddin SM
Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
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Tayo BO
Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA.
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Warren HR
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
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Zhao W
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
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Zhou Y
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
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Matoba N
Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
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Sofer T
Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.
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Alver M
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
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Amini M
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
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Boissel M
CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France.
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Chai JF
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.
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Chen X
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
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Divers J
Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Gandin I
Department of Medical Sciences, University of Trieste, Trieste 34137, Italy.
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Gao C
Department of Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Giulianini F
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
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Goel A
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
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Harris SE
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 2XU, UK.
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Hartwig FP
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil.
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Horimoto ARVR
Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.
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Hsu FC
Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Jackson AU
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
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Kähönen M
Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
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Kasturiratne A
Department of Public Health, University of Kelaniya, Ragama, Sri Lanka.
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Kühnel B
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
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Leander K
Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden.
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Lee WJ
Department of Medical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung 40705, Taiwan.
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Lin KH
Department of Opthalmology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
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'an Luan J
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
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McKenzie CA
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
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Meian H
Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.
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Nelson CP
Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
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Rauramaa R
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland.
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Schupf N
Taub Institute for Research on Alzheimer disease and the Aging Brain, Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
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Scott RA
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
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Sheu WHH
Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-ming University, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Institute of Medical Technology, National Chung-Hsing University, Taichung 40705, Taiwan.
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Stančáková A
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio 70210, Finland.
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Takeuchi F
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan.
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van der Most PJ
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
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Varga TV
Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden.
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Wang H
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
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Wang Y
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
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Ware EB
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA; Institute for Social Research, Research Center for Group Dynamics, University of Michigan, Ann Arbor, MI 48104, USA.
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Weiss S
Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz Arndt University Greifswald, Greifswald 17487, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany.
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Wen W
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
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Yanek LR
General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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Zhang W
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
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Zhao JH
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
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Afaq S
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
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Alfred T
Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA.
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Amin N
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Arking D
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Aung T
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore.
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Barr RG
Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA.
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Bielak LF
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
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Boerwinkle E
Human Genetics Center, The University of Texas School of Public Health, Houston, TX 77030, USA; Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA.
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Bottinger EP
Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA.
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Braund PS
Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
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Brody JA
Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA.
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Broeckel U
Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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Cabrera CP
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
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Cade B
Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
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Caizheng Y
Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.
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Campbell A
Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
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Canouil M
CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France.
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Chakravarti A
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Chauhan G
The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
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Christensen K
Department of Medical Sciences, University of Trieste, Trieste 34137, Italy.
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Cocca M
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
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Collins FS
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands.
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Connell JM
Department of Medicine, University of Kelaniya, Ragama, Sri Lanka.
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de Mutsert R
Inserm U1219 Neuroepidemiology, University of Bordeaux, Bordeaux, France; Department of Neurology, University Hospital, Bordeaux, France; Boston University School of Medicine, Boston, MA 02118, USA.
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de Silva HJ
DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Department of Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany.
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Debette S
Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA.
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Dörr M
Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI 02860, USA.
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Duan Q
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Division of Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
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Eaton CB
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece.
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Ehret G
Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA.
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Evangelou E
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
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Faul JD
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
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Fisher VA
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Forouhi NG
Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem 91120, Israel.
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Franco OH
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK.
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Friedlander Y
Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden.
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Gao H
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
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Gigante B
Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Graff M
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore.
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Gu CC
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK.
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Gu D
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
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Gupta P
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
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Hagenaars SP
University of Eastern Finland, Institute of Biomedicine, Kuopio 70211, Finland.
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Harris TB
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore 119228, Singapore.
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He J
Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku 108-8639, Japan.
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Heikkinen S
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Heng CK
MedStar Health Research Institute, Hyattsville, MD 20782, USA; Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC 20057, USA.
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Hirata M
Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA; Weill Cornell Medicine in Qatar, Doha, Qatar.
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Hofman A
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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Howard BV
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Hunt S
Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA.
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Irvin MR
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
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Jia Y
Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 5650871, Japan; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita 5650871, Japan.
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Joehanes R
Epidemiology, Department of Occupational and Environmental Medicine Program, University of Washington, Seattle, WA 98105, USA.
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Justice AE
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
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Katsuya T
Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore.
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Kaufman J
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore.
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Kerrison ND
Department of Health, National Institute for Health and Welfare, Helsinki 00271, Finland; Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland.
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Khor CC
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland.
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Koh WP
Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA.
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Koistinen HA
Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.
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Komulainen P
Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
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Kooperberg C
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
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Krieger JE
Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Kubo M
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
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Kuusisto J
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
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Langefeld CD
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
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Langenberg C
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
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Launer LJ
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Lehne B
Lifelines cohort study, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
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Lewis CE
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore.
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Li Y
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Lim SH
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore.
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Lin S
WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA.
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Liu CT
Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
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Liu J
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Liu J
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research 138648, Singapore.
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Liu K
Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Liu Y
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
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Loh M
Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.
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Lohman KK
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
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Long J
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
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Louie T
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Human Genetics, Technische Universität München, Munich 80333, Germany.
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Mägi R
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
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Mahajan A
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
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Meitinger T
Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
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Metspalu A
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
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Milani L
Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
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Momozawa Y
Mathematical and Statistical Computing Laboratory, Center for Information Technology, NIH, Bethesda, MD 20892, USA.
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Morris AP
The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UK.
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Mosley TH
Data Tecnica International, Glen Echo, MD 20812, USA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
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Munson P
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Murray AD
Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA.
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Nalls MA
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
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Nasri U
Department of Medicine, University of Ibadan, Ibadan, Nigeria.
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Norris JM
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
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North K
Internal Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA.
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Ogunniyi A
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Padmanabhan S
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA.
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Palmas WR
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
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Palmer ND
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg 85764, Germany.
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Pankow JS
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
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Pedersen NL
Faculty of Medicine, University of Split, Split, Croatia.
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Peters A
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.
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Peyser PA
Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Department of Biobank Research, Umeå University, Umeå, Västerbotten 901 87, Sweden.
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Polasek O
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Raitakari OT
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
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Renström F
Medical Genetics, IRCCS Burlo, Garofolo 34137, Italy.
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Rice TK
Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USA.
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Ridker PM
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
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Robino A
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
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Robinson JG
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore.
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Rose LM
Department of Medicine, University of Ibadan, Ibadan, Nigeria.
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Rudan I
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Sabanayagam C
DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
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Salako BL
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA.
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Sandow K
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
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Schmidt CO
Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
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Schreiner PJ
International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK.
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Scott WR
Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA.
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Seshadri S
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
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Sever P
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
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Sitlani CM
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh EH8 9JZ, UK.
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Smith JA
Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich 81377, Germany.
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Snieder H
Department of Genetics, Stanford University, Stanford, CA 94305, USA.
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Starr JM
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Strauch K
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Life Sciences Institute, National University of Singapore, Singapore, Singapore 117456, Singapore; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546, Singapore.
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Tang H
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore.
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Taylor KD
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Teo YY
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
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Tham YC
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Uitterlinden AG
Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China 100730, China.
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Waldenberger M
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
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Wang L
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Wang YX
Jackson Heart Study, Department of Public Health, Jackson State University, Jackson, MS 39213, USA.
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Wei WB
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Williams C
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Wilson G
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
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Wojczynski MK
Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
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Yao J
General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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Yuan JM
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
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Zonderman AB
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Becker DM
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
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Boehnke M
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Bowden DW
Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden.
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Chambers JC
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK.
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Chen YI
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MA 02142, USA.
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de Faire U
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
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Deary IJ
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
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Esko T
Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Harvard T.H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA 02115, USA; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Västerbotten 901 85, Sweden.
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Farrall M
Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Forrester T
CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France; Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK.
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Franks PW
Department of Medical Sciences, University of Trieste, Trieste 34137, Italy; Division Experimental Genetics, Sidra, Doha 26999, Qatar.
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Freedman BI
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg 85764, Germany.
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Froguel P
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil.
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Gasparini P
Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taipei 11490, Taiwan.
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Gieger C
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim 68167, Germany.
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Horta BL
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan.
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Hung YJ
Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
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Jonas JB
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
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Kato N
Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Lifes Sciences, University of Tampere, Tampere 33014, Finland.
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Kooner JS
School of Medicine, National Yang-ming University, Taipei, Taiwan; Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan; Department of Medicine, China Medical University, Taichung 40705, Taiwan.
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Laakso M
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
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Lehtimäki T
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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Liang KW
Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
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Magnusson PKE
Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil; Genetics, Harvard Medical School, Boston, MA 02115, USA.
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Newman AB
Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
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Oldehinkel AJ
DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute of Physiology, University Medicine Greifswald, Greifswald 17495, Germany.
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Pereira AC
Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
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Redline S
National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
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Rettig R
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
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Samani NJ
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
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Scott J
Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Shu XO
MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
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van der Harst P
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
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Wagenknecht LE
Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA.
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Wareham NJ
Department of Public Health, University of Kelaniya, Ragama, Sri Lanka.
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Watkins H
Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.
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Weir DR
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
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Wickremasinghe AR
Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
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Wu T
Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.
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Zheng W
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
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Kamatani Y
Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA.
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Laurie CC
Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
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Bouchard C
Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
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Cooper RS
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
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Evans MK
Sticht Center for Health Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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Gudnason V
Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
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Kardia SLR
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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Kritchevsky SB
Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington, Health Research Institute, Seattle, WA 98101, USA.
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Levy D
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
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O'Connell JR
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA.
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Psaty BM
Dean's Office, University of Kentucky College of Public Health, Lexington, KY 40536, USA.
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van Dam RM
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden 2300RC, the Netherlands.
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Sims M
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
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Arnett DK
Cardiology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
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Mook-Kanamori DO
Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
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Kelly TN
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
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Fox ER
Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
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Hayward C
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Fornage M
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Rotimi CN
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
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Province MA
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore.
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van Duijn CM
Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA; Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, New York, NY 10029, USA.
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Tai ES
Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA.
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Wong TY
Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA; Genomic Outcomes, Department of Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
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Loos RJF
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
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Reiner AP
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Rotter JI
Division of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90032, USA.
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Zhu X
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
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Bierut LJ
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK.
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Gauderman WJ
Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.
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Caulfield MJ
William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
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Elliott P
Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA.
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Rice K
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA.
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Munroe PB
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Morrison AC
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: dchasman@research.bwh.harvard.edu.
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Cupples LA
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Rao DC
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Chasman DI
Show more…
Published in:
- American journal of human genetics. - 2018
English
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 × 10-8) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 × 10-8). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling (MSRA, EBF2).
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bronze
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https://folia.unifr.ch/global/documents/70122
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