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18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma.
Journal article

18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma.

  • Papadakis GZ From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda; †PET-Department, Clinical Center, National Institutes of Health, Bethesda, MD; ‡Leeds Medical School, Leeds, UK; §Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida (UCF), Orlando, FL; ∥Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; ¶Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; and **Department of Radiology, Medical School, University of Crete, Crete, Greece.
  • Millo C
  • Jassel IS
  • Bagci U
  • Sadowski SM
  • Karantanas AH
  • Patronas NJ
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  • 2016-12-30
Published in:
  • Clinical nuclear medicine. - 2017
Adult
Fluorodeoxyglucose F18
Gallium Radioisotopes
Hemangioblastoma
Humans
Magnetic Resonance Imaging
Male
Organometallic Compounds
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
Receptors, Somatostatin
Retinal Neoplasms
von Hippel-Lindau Disease
English Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased Ga-DOTATATE activity, suggesting cell-surface overexpression of somatostatin receptors. The presented case indicates the clinical applications of somatostatin receptor imaging with Ga-DOTA-conjugated peptides in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of sporadic retinal hemangioblastomas, which may have similar features on MRI with other retinal tumors.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/69976
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