Back
Novel findings in neutrophil biology and their impact on cardiovascular disease.
Journal article

Novel findings in neutrophil biology and their impact on cardiovascular disease.

  • Bonaventura A First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, Genoa, Italy.
  • Montecucco F First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 6 viale Benedetto XV, Genoa, Italy.
  • Dallegri F First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, Genoa, Italy.
  • Carbone F First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, Genoa, Italy.
  • Lüscher TF Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, Schlieren, Switzerland.
  • Camici GG Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, Schlieren, Switzerland.
  • Liberale L First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, Genoa, Italy.
Show more…
  • 2019-03-29
Published in:
  • Cardiovascular research. - 2019
Heart failure
Microvesicles
Myocardial infarction
NETs
Neutrophils
Stroke
Animals
Anti-Inflammatory Agents
Atherosclerosis
Cardiovascular Diseases
Cardiovascular System
Humans
Myocardial Infarction
Neutrophil Activation
Neutrophils
Signal Transduction
Stroke
English Neutrophils are the most abundant circulating leucocytes in healthy humans. These cells are central players during acute inflammatory responses, although a growing body of evidence supports a crucial role in chronic inflammation and chemokines and cytokines related to it as well. Thus, both humoral and cellular components are involved in the development of plaque formation and atherosclerosis. Accordingly, CANTOS trial using an interleukin-1 beta antibody confirmed that inflammatory cytokines contribute to the occurrence of myocardial infarction and cardiac death independent of changes in lipids. Recent data revealed that neutrophils are a heterogeneous population with different subsets and functional characteristics (i.e. CD177+ cells, OLFM4+ neutrophils, proangiogenic neutrophils, neutrophils undergoing reverse migration, and aged neutrophils). Importantly, neutrophils are able to synthesize de novo proteins. Neutrophil extracellular trap generation and NETosis have been considered as very important weapons in sterile inflammation. Neutrophil-derived microvesicles represent another mechanism by which neutrophils amplify inflammatory processes, being found at high levels both at the site of injury and in the bloodstream. Finally, neutrophil aging can influence their functions also in relation with host age. These recent acquisitions in the field of neutrophil biology might pave the way for new therapeutic targets to prevent or even treat patients experiencing cardiovascular (CV) diseases. Here, we discuss novel findings in neutrophil biology, their impact on CV and cerebrovascular diseases, and the potential implementation of these notions into daily clinical practice.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/6892
Statistics
Document views: 8 File downloads: