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Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapy.
Journal article

Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapy.

  • 2011-06-11
Published in:
  • Biochemical pharmacology. - 2011
Animals
Antibodies, Monoclonal
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Autoimmune Diseases
Clinical Trials as Topic
Drug Delivery Systems
Hematologic Diseases
Humans
Immunotherapy
Inflammation Mediators
Lectins
Sialic Acid Binding Ig-like Lectin 2
Sialic Acid Binding Ig-like Lectin 3
Sialic Acid Binding Immunoglobulin-like Lectins
Sialic Acids
English The immune system must be tightly held in check to avoid bystander tissue damage as well as autoreactivity caused by overwhelming immune reactions. A novel family of immunoregulatory, carbohydrate-binding receptors, the Siglecs (sialic acid binding immunoglobulin-like lectins), has received particular attention in light of their capacity to mediate cell death, anti-proliferative effects and to regulate a variety of cellular activities. Siglec receptors are mainly expressed on leukocytes in a cell type-specific and differentiation-dependent manner. Siglecs might potentially be exploited as targets of novel immune- and glycotherapeutics for cell-directed therapies in autoimmune and allergic diseases, as well as in haematologic malignancies. Here we present novel insights on structural and functional characteristics, expression patterns and evolutionary aspects of Siglecs and their ligands. Pharmacological strategies using Siglec agonistic cross-linking therapeutics, such as monoclonal or engineered antibodies, intravenous immunoglobulin (IVIG), or glycomimetics are discussed. Modulation of immune responses by targeting Siglecs using agonistic or antagonistic therapeutics may have important clinical implications and may pave the way for novel pharmacological avenues for the treatment of autoimmune and allergic diseases or for tumor immunotherapy.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/6729
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