The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.
- Lande R 1] Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, 00100 Rome, Italy [2] Department of Dermatology, University Hospital CHUV, 1011 Lausanne, Switzerland.
- Botti E Dermatology Unit, NESMOS Department, Sapienza University of Rome, 00100 Rome, Italy.
- Jandus C Translational tumor immunology group, Ludwig center for cancer research of the University of Lausanne, Lausanne 1066, Switzerland.
- Dojcinovic D TC Metrix, Epalinge 1066, Switzerland.
- Fanelli G Department of Biology and Biotechnology 'C. Darwin', University La Sapienza, Rome, 00100 Italy.
- Conrad C Department of Dermatology, University Hospital CHUV, 1011 Lausanne, Switzerland.
- Chamilos G Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
- Feldmeyer L Department of Dermatology, University Hospital CHUV, 1011 Lausanne, Switzerland.
- Marinari B Department of Dermatology, University Tor Vergata, 00100 Rome, Italy.
- Chon S Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
- Vence L Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
- Riccieri V Division of Rheumatology, Department of Clinical Medicine and Therapy, University La Sapienza, 00100 Rome, Italy.
- Guillaume P TC Metrix, Epalinge 1066, Switzerland.
- Navarini AA Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland.
- Romero P TC Metrix, Epalinge 1066, Switzerland.
- Costanzo A 1] Dermatology Unit, NESMOS Department, Sapienza University of Rome, 00100 Rome, Italy [2] Translational tumor immunology group, Ludwig center for cancer research of the University of Lausanne, Lausanne 1066, Switzerland.
- Piccolella E Department of Biology and Biotechnology 'C. Darwin', University La Sapienza, Rome, 00100 Italy.
- Gilliet M Department of Dermatology, University Hospital CHUV, 1011 Lausanne, Switzerland.
- Frasca L 1] Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, 00100 Rome, Italy [2] Department of Dermatology, University Hospital CHUV, 1011 Lausanne, Switzerland.
- 2014-12-04
Published in:
- Nature communications. - 2014
Antimicrobial Cationic Peptides
Autoantigens
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Case-Control Studies
Cathelicidins
Humans
Immunohistochemistry
Psoriasis
Severity of Illness Index
T-Lymphocytes
English
Psoriasis is a common T-cell-mediated skin disease with 2-3% prevalence worldwide. Psoriasis is considered to be an autoimmune disease, but the precise nature of the autoantigens triggering T-cell activation remains poorly understood. Here we find that two-thirds of patients with moderate-to-severe plaque psoriasis harbour CD4(+) and/or CD8(+) T cells specific for LL37, an antimicrobial peptide (AMP) overexpressed in psoriatic skin and reported to trigger activation of innate immune cells. LL37-specific T cells produce IFN-γ, and CD4(+) T cells also produce Th17 cytokines. LL37-specific T cells can infiltrate lesional skin and may be tracked in patients blood by tetramers staining. Presence of circulating LL37-specific T cells correlates significantly with disease activity, suggesting a contribution to disease pathogenesis. Thus, we uncover a role of LL37 as a T-cell autoantigen in psoriasis and provide evidence for a role of AMPs in both innate and adaptive immune cell activation.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1038/ncomms6621
- PMID 25470744
- Persistent URL
- https://folia.unifr.ch/global/documents/66030
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