Journal article
Iridium-catalyzed enantioselective allylic vinylation.
- Hamilton JY Eidgenössische Technische Hochschule Zürich, HCI H335, 8093 Zürich, Switzerland.
- Sarlah D
- Carreira EM
- 2012-12-22
Published in:
- Journal of the American Chemical Society. - 2013
Alkenes
Borates
Catalysis
Iridium
Molecular Structure
Organometallic Compounds
Propanols
Stereoisomerism
English
The first example of Ir-catalyzed asymmetric substitution reaction with vinyl trifluoroborates is described. The direct reaction between branched, racemic allylic alcohols and potassium alkenyltrifluoroborates proceeded with high site selectivity and excellent enantioselectivity (up to 99%) mediated by an Ir-(P,olefin) complex. This method allows rapid access to various 1,4-dienes or trienes including the biologically active natural products (-)-nyasol and (-)-hinokiresinol.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1021/ja311422z
- PMID 23256708
- Persistent URL
- https://folia.unifr.ch/global/documents/64849
Statistics
Document views: 23
File downloads: