A study on mastectomy samples to evaluate breast imaging quality and potential clinical relevance of differential phase contrast mammography.
- Hauser N From the *Department of Gynecology and Obstetrics, Interdisciplinary Breast Center Baden, Kantonsspital Baden, Baden; †Swiss Light Source, Paul Scherrer Institute, Villigen; ‡Department of Radiology, §Institute of Pathology, Kantonsspital Baden, Baden, Switzerland; ∥Philips Research Laboratories, Innovative Technologies; ¶Philips Medical Systems DMC GmbH, Hamburg, Germany; and #Institute for Biomedical Engineering, University and Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland.
- Wang Z
- Kubik-Huch RA
- Trippel M
- Singer G
- Hohl MK
- Roessl E
- Köhler T
- van Stevendaal U
- Wieberneit N
- Stampanoni M
- 2013-10-22
Published in:
- Investigative radiology. - 2014
Adult
Aged
Aged, 80 and over
Algorithms
Breast Neoplasms
Feasibility Studies
Female
Humans
In Vitro Techniques
Male
Mammography
Mastectomy
Middle Aged
Observer Variation
Radiographic Image Enhancement
Radiographic Image Interpretation, Computer-Assisted
Reproducibility of Results
Sensitivity and Specificity
English
OBJECTIVES
Differential phase contrast and scattering-based x-ray mammography has the potential to provide additional and complementary clinically relevant information compared with absorption-based mammography. The purpose of our study was to provide a first statistical evaluation of the imaging capabilities of the new technique compared with digital absorption mammography.
MATERIALS AND METHODS
We investigated non-fixed mastectomy samples of 33 patients with invasive breast cancer, using grating-based differential phase contrast mammography (mammoDPC) with a conventional, low-brilliance x-ray tube. We simultaneously recorded absorption, differential phase contrast, and small-angle scattering signals that were combined into novel high-frequency-enhanced images with a dedicated image fusion algorithm. Six international, expert breast radiologists evaluated clinical digital and experimental mammograms in a 2-part blinded, prospective independent reader study. The results were statistically analyzed in terms of image quality and clinical relevance.
RESULTS
The results of the comparison of mammoDPC with clinical digital mammography revealed the general quality of the images to be significantly superior (P < 0.001); sharpness, lesion delineation, as well as the general visibility of calcifications to be significantly more assessable (P < 0.001); and delineation of anatomic components of the specimens (surface structures) to be significantly sharper (P < 0.001). Spiculations were significantly better identified, and the overall clinically relevant information provided by mammoDPC was judged to be superior (P < 0.001).
CONCLUSIONS
Our results demonstrate that complementary information provided by phase and scattering enhanced mammograms obtained with the mammoDPC approach deliver images of generally superior quality. This technique has the potential to improve radiological breast diagnostics.
Differential phase contrast and scattering-based x-ray mammography has the potential to provide additional and complementary clinically relevant information compared with absorption-based mammography. The purpose of our study was to provide a first statistical evaluation of the imaging capabilities of the new technique compared with digital absorption mammography.
MATERIALS AND METHODS
We investigated non-fixed mastectomy samples of 33 patients with invasive breast cancer, using grating-based differential phase contrast mammography (mammoDPC) with a conventional, low-brilliance x-ray tube. We simultaneously recorded absorption, differential phase contrast, and small-angle scattering signals that were combined into novel high-frequency-enhanced images with a dedicated image fusion algorithm. Six international, expert breast radiologists evaluated clinical digital and experimental mammograms in a 2-part blinded, prospective independent reader study. The results were statistically analyzed in terms of image quality and clinical relevance.
RESULTS
The results of the comparison of mammoDPC with clinical digital mammography revealed the general quality of the images to be significantly superior (P < 0.001); sharpness, lesion delineation, as well as the general visibility of calcifications to be significantly more assessable (P < 0.001); and delineation of anatomic components of the specimens (surface structures) to be significantly sharper (P < 0.001). Spiculations were significantly better identified, and the overall clinically relevant information provided by mammoDPC was judged to be superior (P < 0.001).
CONCLUSIONS
Our results demonstrate that complementary information provided by phase and scattering enhanced mammograms obtained with the mammoDPC approach deliver images of generally superior quality. This technique has the potential to improve radiological breast diagnostics.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1097/RLI.0000000000000001
- PMID 24141742
- Persistent URL
- https://folia.unifr.ch/global/documents/57662
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