The genetic architecture of human brainstem structures and their involvement in common brain disorders.
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Elvsåshagen T
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. torbjorn.elvsashagen@medisin.uio.no.
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Bahrami S
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. shahram.bahrami@medisin.uio.no.
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van der Meer D
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Agartz I
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
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Alnæs D
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Barch DM
Departments of Psychological & Brain Sciences, Psychiatry, and Radiology, Washington University in St. Louis, St. Louis, USA.
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Baur-Streubel R
Department of Psychology I and Centre of Mental Health, University of Würzburg, Würzburg, Germany.
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Bertolino A
Institute of Psychiatry, University of Bari, Bari, Italy.
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Beyer MK
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
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Blasi G
Institute of Psychiatry, University of Bari, Bari, Italy.
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Borgwardt S
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
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Boye B
Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Buitelaar J
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
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Bøen E
Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Celius EG
Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
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Cervenka S
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
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Conzelmann A
Children and Adolescence Psychiatry, University of Tübingen, Tübingen, Germany.
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Coynel D
Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland.
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Di Carlo P
Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
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Djurovic S
Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
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Eisenacher S
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
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Espeseth T
Department of Psychology, University of Oslo, Oslo, Norway.
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Fatouros-Bergman H
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
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Flyckt L
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
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Franke B
Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
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Frei O
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Gelao B
Institute of Psychiatry, University of Bari, Bari, Italy.
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Harbo HF
Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
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Hartman CA
Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
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Håberg A
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
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Heslenfeld D
Clinical Neuropsychology section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
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Hoekstra PJ
Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
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Høgestøl EA
Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
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Jonassen R
Department of Psychology, University of Oslo, Oslo, Norway.
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Jönsson EG
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Kirsch P
Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
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Kłoszewska I
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Lagerberg TV
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
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Landrø NI
NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.
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Le Hellard S
Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
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Lesch KP
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Maglanoc LA
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
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Malt UF
Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
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Mecocci P
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Melle I
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
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Meyer-Lindenberg A
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Moberget T
The CatoSenteret Rehabilitation Center, Son, Norway.
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Nordvik JE
Departments of Radiation Sciences and Integrative Medical Biology, Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
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Nyberg L
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Connell KSO
Clinical Neuropsychology section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
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Oosterlaan J
Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
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Papalino M
Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland.
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Papassotiropoulos A
Department of Psychology I and Centre of Mental Health, University of Würzburg, Würzburg, Germany.
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Pauli P
Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
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Pergola G
Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
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Persson K
Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland.
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de Quervain D
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
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Reif A
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Rokicki J
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
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van Rooij D
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Shadrin AA
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
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Schmidt A
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
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Schwarz E
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
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Selbæk G
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
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Soininen H
Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
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Sowa P
NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.
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Steen VM
1st University Department of Neurology, Aristotle University of Thessaloniki, Makedonia, Greece.
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Tsolaki M
INSERM U 1027, University of Toulouse, Toulouse, France.
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Vellas B
Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
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Wang L
Institute of Psychiatry, King's College, London, UK.
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Westman E
Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
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Ziegler GC
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
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Zink M
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Andreassen OA
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
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Westlye LT
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. tobias.kaufmann@medisin.uio.no.
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Kaufmann T
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Published in:
- Nature communications. - 2020
English
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
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Language
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Open access status
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gold
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Identifiers
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Persistent URL
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https://folia.unifr.ch/global/documents/54062
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