STROBE-MR: Guidelines for strengthening the reporting of Mendelian randomization studies
- Davey Smith, George ORCID Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
- Davies, Neil M Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
- Dimou, Niki Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
- Egger, Matthias ORCID Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
- Gallo, Valentina School of Public Health, Imperial College London, London, United Kingdom
- Golub, Robert Deputy Editor, JAMA, Chicago, Illinois, United States of America
- Higgins, Julian PT NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom
- Langenberg, Claudia MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
- Loder, Elizabeth W Harvard Medical School, Boston, Massachusetts, United States of America
- Richards, J Brent Department of Twin Research and Genetic Epidemiology, King's College London, University of London, London, United Kingdom
- Richmond, Rebecca C Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
- Skrivankova, Veronika W ORCID Institute of Social and Preventive Medicine, University of Berne, Bern, Switzerland
- Swanson, Sonja A Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
- Timpson, Nicholas J Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
- Tybjaerg-Hansen, Anne Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- VanderWeele, Tyler J Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America
- Woolf, Benjamin AR ORCID Department of Psychological Science, University of Bristol, Bristol, United Kingdom
- Yarmolinsky, James Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
English
While the number of studies using Mendelian randomization (MR) methods has grown exponentially in the last decade, the quality of reporting of these studies often has been poor. Similar to other reporting guidelines such as CONSORT (Consolidated Standards of Reporting Trials ) for randomised trials and STROBE (STrenghtening the Reporting of Observational studies in Epidemiology )
Empirical evidence indicates that many reports of MR studies do not clearly state or examine the various assumptions of MR methods and report insufficient details on the data sources, which makes it hard to evaluate the quality and reliability of the results. The STROBE-MR guidance covers both one sample and two sample MR studies. At present, the draft checklist consists of 20 items, organized into the title and abstract, introduction, methods, results and discussion sections of articles.
As these guidelines aim to reach the entire MR community, we would like to give everyone the opportunity to contribute their comments. The following draft of the STROBE-MR checklist is open for public discussion and all feedback will be taken into account during its next revision. For feedback, please use the comment section below this post on PeerJ Preprints.
We hope the final guidelines will serve the entire community and contribute to improving the reporting of MR studies in the future.
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- https://folia.unifr.ch/global/documents/53711
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