Back
Full-text
Journal article

Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis.

  • Pepper MS Department of Morphology, University Medical Center, Geneva, Switzerland. michael.pepper@medecine.unige.ch
  • 2001-07-14
Published in:
  • Arteriosclerosis, thrombosis, and vascular biology. - 2001
Animals
Extracellular Matrix
Fibrinolysin
Fibrinolysis
Matrix Metalloproteinases
Matrix Metalloproteinases, Membrane-Associated
Metalloendopeptidases
Neoplasms
Neovascularization, Pathologic
Plasminogen Activator Inhibitor 1
Plasminogen Activators
Receptors, Cell Surface
Receptors, Urokinase Plasminogen Activator
Tissue Plasminogen Activator
Urokinase-Type Plasminogen Activator
English Extracellular proteolysis is an absolute requirement for new blood vessel formation (angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and plasminogen activator (PA)-plasmin systems during angiogenesis. Specifically, a role for gelatinases (MMP-2, MMP-9), membrane-type 1 MMP (MMP-14), the urokinase-type PA receptor, and PA inhibitor 1 has been clearly defined in a number of model systems. The MMP and PA-plasmin systems have also been implicated in experimental vascular tumor formation, and their role during this process will be examined. Antiproteolysis, particularly in the context of angiogenesis, has become a key target in therapeutic strategies aimed at inhibiting tumor growth and other diseases associated with neovascularization.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/53200
Statistics
Document views: 8 File downloads:
  • fulltext.pdf: 0