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Iron phosphate nanoparticles for food fortification: Biological effects in rats and human cell lines.
Journal article

Iron phosphate nanoparticles for food fortification: Biological effects in rats and human cell lines.

  • von Moos LM a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Schneider M a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Hilty FM a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Hilbe M b Institute of Veterinary Pathology, University of Zurich-Vetsuisse , Switzerland.
  • Arnold M a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Ziegler N a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Mato DS a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Winkler H c Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse , Switzerland.
  • Tarik M d Energy and Environment Research Division , Paul Scherrer Institute (PSI) , Switzerland.
  • Ludwig C d Energy and Environment Research Division , Paul Scherrer Institute (PSI) , Switzerland.
  • Naegeli H c Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse , Switzerland.
  • Langhans W a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Zimmermann MB a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Sturla SJ a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
  • Trantakis IA a Department of Health Sciences and Technology , ETH Zürich , Switzerland.
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  • 2017-04-04
Published in:
  • Nanotoxicology. - 2017
Iron phosphate nanoparticles
food fortification
in vitro
in vivo
nanotoxicology
Animals
Biological Availability
Cell Survival
Diet
Dose-Response Relationship, Drug
Ferric Compounds
Food, Fortified
Glutathione
HT29 Cells
Humans
Iron Overload
Male
Nanoparticles
Oxidative Stress
Rats
Rats, Sprague-Dawley
English Nanotechnology offers new opportunities for providing health benefits in foods. Food fortification with iron phosphate nanoparticles (FePO4 NPs) is a promising new approach to reducing iron deficiency because FePO4 NPs combine high bioavailability with superior sensory performance in difficult to fortify foods. However, their safety remains largely untested. We fed rats for 90 days diets containing FePO4 NPs at doses at which iron sulfate (FeSO4), a commonly used food fortificant, has been shown to induce adverse effects. Feeding did not result in signs of toxicity, including oxidative stress, organ damage, excess iron accumulation in organs or histological changes. These safety data were corroborated by evidence that NPs were taken up by human gastrointestinal cell lines without reducing cell viability or inducing oxidative stress. Our findings suggest FePO4 NPs appear to be as safe for ingestion as FeSO4.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/50403
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