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Drosophila adult muscle development and regeneration.
Journal article

Drosophila adult muscle development and regeneration.

  • Gunage RD National Centre for Biological Sciences, Tata Institute of Fundamental Research, India; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, United States.
  • Dhanyasi N National Centre for Biological Sciences, Tata Institute of Fundamental Research, India; Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, United States.
  • Reichert H Biozentrum, University of Basel, Basel, Switzerland.
  • VijayRaghavan K National Centre for Biological Sciences, Tata Institute of Fundamental Research, India. Electronic address: vijay@ncbs.res.in.
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  • 2017-11-18
Published in:
  • Seminars in cell & developmental biology. - 2017
Epithelial tissue
Muscle stem cell
Myoblast fusion
Myoblasts
Myogenesis
Niche
Satellite cell
Zfh-1
stripe
Animals
Drosophila
Gene Expression Regulation, Developmental
Models, Genetic
Morphogenesis
Muscle Development
Muscle Fibers, Skeletal
Muscles
Myoblasts
Regeneration
English Myogenesis is a highly orchestrated, complex developmental process by which cell lineages that are mesodermal in origin generate differentiated multinucleate muscle cells as a final product. Considerable insight into the process of myogenesis has been obtained for the embryonic development of the larval muscles of Drosophila. More recently, the postembryonic development of the muscles of the adult fly has become a focus of experimental investigation of myogenesis since specific flight muscles of the fly manifest remarkable similarities to vertebrate muscles in their development and organization. In this review, we catalog some of the milestones in the study of myogenesis in the large adult-specific flight muscles of Drosophila. The identification of mesoderm-derived muscle stem cell lineages, the characterization of the symmetric and asymmetric divisions through which they produce adult-specific myoblasts, the multifaceted processes of myoblast fusion, and the unexpected discovery of quiescent satellite cells that can be activated by injury are discussed. Moreover, the finding that all of these processes incorporate a plethora of signaling interactions with other myogenic cells and with niche-like neighboring tissue is considered. Finally, we briefly point out possible future developments in the area of Drosophila myogenesis that may lead to of new avenues of genetic research into the roles of muscle stem cells in development, disease and aging.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/49609
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