Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites.

• Mizukawa Y Drug Discovery Science Research Center, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan; Synstar Japan Co., Ltd, Orbic Bldg 3F, 2-9-46 Sakaecho, Odawara 250-0011, Japan.
• Ge JF Drug Discovery Science Research Center, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215006, China.
• Bakar Md A Drug Discovery Science Research Center, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan; Center for Advanced Research in Sciences, University of Dhaka, Bangladesh.
• Itoh I Drug Discovery Science Research Center, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan; Synstar Japan Co., Ltd, Orbic Bldg 3F, 2-9-46 Sakaecho, Odawara 250-0011, Japan.
• Scheurer C Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
• Wittlin S Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
• Brun R Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
• Matsuoka H School of Medicine, Department of Infection and Immunity, Division of Medical Zoology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi 329-0498, Japan.
• Ihara M Drug Discovery Science Research Center, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan. Electronic address: m-ihara@hoshi.ac.jp.

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Antimalarial

Benzo[a]phenoxazine

Drug-sensitive and drug-resistant

Metabolites

Plasmodium falciparum

Antimalarials

Dose-Response Relationship, Drug

Microbial Sensitivity Tests

Molecular Structure

Oxazines

Parasitic Sensitivity Tests

Plasmodium falciparum

Pyridines

Structure-Activity Relationship