The digestive tract of Drosophila melanogaster.
- Lemaitre B Global Health Institute, School of Life Sciences, École Polytechnique Fédérale Lausanne (EPFL), CH-1015 Lausanne, Switzerland; email: bruno.lemaitre@epfl.ch.
- Miguel-Aliaga I
- 2013-09-11
Published in:
- Annual review of genetics. - 2013
Animals
Diet
Digestion
Digestive System
Drosophila Proteins
Drosophila melanogaster
Energy Metabolism
Enteric Nervous System
Enteroendocrine Cells
Epithelial Cells
Gastrointestinal Hormones
Host-Pathogen Interactions
Intestinal Absorption
Larva
Longevity
Mucus
English
The digestive tract plays a central role in the digestion and absorption of nutrients. Far from being a passive tube, it provides the first line of defense against pathogens and maintains energy homeostasis by exchanging neuronal and endocrine signals with other organs. Historically neglected, the gut of the fruit fly Drosophila melanogaster has recently come to the forefront of Drosophila research. Areas as diverse as stem cell biology, neurobiology, metabolism, and immunity are benefitting from the ability to study the genetics of development, growth regulation, and physiology in the same organ. In this review, we summarize our knowledge of the Drosophila digestive tract, with an emphasis on the adult midgut and its functional underpinnings.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1146/annurev-genet-111212-133343
- PMID 24016187
- Persistent URL
- https://folia.unifr.ch/global/documents/48655
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