Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
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Watson HJ
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Yilmaz Z
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Thornton LM
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Hübel C
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Coleman JRI
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Gaspar HA
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Bryois J
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Hinney A
Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
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Leppä VM
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Mattheisen M
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
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Medland SE
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Ripke S
Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
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Yao S
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Giusti-Rodríguez P
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Hanscombe KB
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Purves KL
Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
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Adan RAH
Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
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Alfredsson L
NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.
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Ando T
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Andreassen OA
Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
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Baker JH
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
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Berrettini WH
INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
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Boehm I
Wellcome Sanger Institute, Hinxton, UK.
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Boni C
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
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Perica VB
Department of Child and Adolescent Psychiatry, Klinikum Frankfurt/Oder, Frankfurt, Germany.
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Buehren K
Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
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Burghardt R
Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
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Cassina M
Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
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Cichon S
Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
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Clementi M
Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.
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Cone RD
Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
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Courtet P
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Crow S
Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands.
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Crowley JJ
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
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Danner UN
Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.
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Davis OSP
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
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de Zwaan M
Department of Neurosciences, University of Padova, Padova, Italy.
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Dedoussis G
College of Nursing, Seattle University, Seattle, WA, USA.
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Degortes D
Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
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DeSocio JE
Department of Psychiatry, Athens University Medical School, Athens University, Athens, Greece.
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Dick DM
L'institut du thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
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Dikeos D
Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
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Dina C
Barcelona Institute of Science and Technology, Barcelona, Spain.
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Dmitrzak-Weglarz M
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
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Docampo E
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Centre for Mental Health, Würzburg, Germany.
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Duncan LE
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
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Egberts K
Barcelona Institute of Science and Technology, Barcelona, Spain.
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Ehrlich S
Estonian Genome Center, University of Tartu, Tartu, Estonia.
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Escaramís G
Barcelona Institute of Science and Technology, Barcelona, Spain.
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Esko T
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Estivill X
Department of Neurosciences, University of Padova, Padova, Italy.
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Farmer A
Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain.
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Favaro A
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany.
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Fernández-Aranda F
Estonian Genome Center, University of Tartu, Tartu, Estonia.
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Fichter MM
Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
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Fischer K
Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
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Föcker M
Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
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Foretova L
Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
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Forstner AJ
Wellcome Sanger Institute, Hinxton, UK.
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Forzan M
Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
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Franklin CS
Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.
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Gallinger S
Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
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Giegling I
First Psychiatric Department, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.
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Giuranna J
INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
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Gonidakis F
Barcelona Institute of Science and Technology, Barcelona, Spain.
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Gorwood P
Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.
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Mayora MG
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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Guillaume S
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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Guo Y
Wellcome Sanger Institute, Hinxton, UK.
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Hakonarson H
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
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Hatzikotoulas K
Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
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Hauser J
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Hebebrand J
Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
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Helder SG
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
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Herms S
Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.
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Herpertz-Dahlmann B
Wellcome Sanger Institute, Hinxton, UK.
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Herzog W
Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, MA, USA.
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Huckins LM
Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany.
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Hudson JI
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan.
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Imgart H
Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic.
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Inoko H
Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain.
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Janout V
Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
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Jiménez-Murcia S
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Julià A
Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
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Kalsi G
Department of Public Health, University of Helsinki, Helsinki, Finland.
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Kaminská D
Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
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Kaprio J
Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
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Karhunen L
Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
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Karwautz A
Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
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Kas MJH
Department of Public Health, University of Helsinki, Helsinki, Finland.
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Kennedy JL
Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
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Keski-Rahkonen A
Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea.
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Kiezebrink K
Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
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Kim YR
Department of Psychology, Michigan State University, East Lansing, MI, USA.
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Klareskog L
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
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Klump KL
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Knudsen GPS
Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway.
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La Via MC
Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
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Le Hellard S
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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Levitan RD
American School of Professional Psychology, Argosy University, Northern Virginia, Arlington, VA, USA.
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Li D
Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
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Lilenfeld L
Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland.
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Lin BD
Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
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Lissowska J
BESE Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
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Luykx J
Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
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Magistretti PJ
Estonian Genome Center, University of Tartu, Tartu, Estonia.
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Maj M
Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
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Mannik K
Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
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Marsal S
NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.
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Marshall CR
Department of Psychiatry, University College Cork, Cork, Ireland.
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Mattingsdal M
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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McDevitt S
Estonian Genome Center, University of Tartu, Tartu, Estonia.
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McGuffin P
Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
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Metspalu A
Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
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Meulenbelt I
National Center for PTSD, VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
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Micali N
Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
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Mitchell K
Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
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Monteleone AM
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Monteleone P
Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
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Munn-Chernoff MA
Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
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Nacmias B
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
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Navratilova M
Kartini Clinic, Portland, OR, USA.
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Ntalla I
Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
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O'Toole JK
Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
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Ophoff RA
Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
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Padyukov L
INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
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Palotie A
Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
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Pantel J
Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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Papezova H
Saint Joan de Déu Research Institute, Saint Joan de Déu Barcelona Children's Hospital, Barcelona, Spain.
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Pinto D
Department of Public Health, University of Helsinki, Helsinki, Finland.
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Rabionet R
INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
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Raevuori A
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
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Ramoz N
Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
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Reichborn-Kjennerud T
Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
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Ricca V
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
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Ripatti S
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Ritschel F
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Pisa, Italy.
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Roberts M
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany.
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Rotondo A
Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
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Rujescu D
Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy.
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Rybakowski F
Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
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Santonastaso P
Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
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Scherag A
National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
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Scherer SW
J. Craig Venter Institute (JCVI), La Jolla, CA, USA.
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Schmidt U
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
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Schork NJ
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
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Schosser A
Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
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Seitz J
Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
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Slachtova L
Center for Eating Disorders Ursula, Rivierduinen, Leiden, the Netherlands.
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Slagboom PE
Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
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Slof-Op 't Landt MCT
Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
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Slopien A
Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
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Sorbi S
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Świątkowska B
Wellcome Sanger Institute, Hinxton, UK.
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Szatkiewicz JP
Department of Neurosciences, University of Padova, Padova, Italy.
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Tachmazidou I
Department of Psychiatry, University of Naples SUN, Naples, Italy.
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Tenconi E
Brain Sciences Department, Stremble Ventures, Limassol, Cyprus.
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Tortorella A
National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
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Tozzi F
Adolescent Health Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.
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Treasure J
Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
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Tsitsika A
Pediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.
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Tyszkiewicz-Nwafor M
Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands.
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Tziouvas K
Center for Eating Disorders Ursula, Rivierduinen, Leiden, the Netherlands.
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van Elburg AA
Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
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van Furth EF
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
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Wagner G
Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
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Walton E
Wellcome Sanger Institute, Hinxton, UK.
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Widen E
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Zeggini E
Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany.
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Zerwas S
BioRealm, LLC, Walnut, CA, USA.
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Zipfel S
Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
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Bergen AW
The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.
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Boden JM
The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.
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Brandt H
Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
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Crawford S
Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
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Halmi KA
Eating Recovery Center, Denver, CO, USA.
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Horwood LJ
Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
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Johnson C
Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
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Kaplan AS
Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.
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Kaye WH
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Mitchell JE
Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand.
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Olsen CM
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Pearson JF
Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
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Pedersen NL
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
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Strober M
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Werge T
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
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Whiteman DC
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Woodside DB
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Stuber GD
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
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Gordon S
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
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Grove J
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Henders AK
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Juréus A
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
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Kirk KM
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Larsen JT
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
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Parker R
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
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Petersen L
Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
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Jordan J
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Kennedy M
School of Psychology, Flinders University, Adelaide, South Australia, Australia.
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Montgomery GW
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
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Wade TD
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Birgegård A
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
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Lichtenstein P
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Norring C
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
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Landén M
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
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Martin NG
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Mortensen PB
Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
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Sullivan PF
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cynthia_bulik@med.unc.edu.
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Breen G
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Bulik CM
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English
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
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green
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https://folia.unifr.ch/global/documents/46870
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