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The ARRIVE guidelines 2.0: updated guidelines for reporting animal research.

  • Percie du Sert N Head of Experimental Design and Reporting, NC3Rs, London, United Kingdom.
  • Hurst V Science Manager - Experimental Design and Reporting, NC3Rs, London, United Kingdom.
  • Ahluwalia A Professor of Vascular Pharmacology, Co-Director, The William Harvey Research Institute, London, United Kingdom.
  • Alam S Director of Publishing Ethics and Integrity, Taylor & Francis Group, London, United Kingdom.
  • Avey MT Lead Health Scientist, Health Science Practice, ICF, Durham, North Carolina, United States of America.
  • Baker M Senior Editor, Opinion, Nature, San Francisco, California, United States of America.
  • Browne WJ Professor of Statistics, School of Education, University of Bristol, Bristol, United Kingdom.
  • Clark A Senior Editor, Team Manager - Life Sciences, PLOS ONE, Cambridge, United Kingdom.
  • Cuthill IC Professor of Behavioural Ecology, School of Biological Sciences, University of Bristol, Bristol, United Kingdom.
  • Dirnagl U Director, QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
  • Emerson M Reader in Platelet Pharmacology, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Garner P Professor, and Director of the Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Holgate ST MRC Clinical Professor, Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
  • Howells DW Professor of Neuroscience and Brain Plasticity, Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
  • Karp NA Principal Scientist - Statistician & UK Team Lead, Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
  • Lazic SE Chief Scientific Officer, Prioris.ai Inc, Ottawa, Canada.
  • Lidster K Programme Manager - Animal Welfare, NC3Rs, London, United Kingdom.
  • MacCallum CJ Director of Open Science, Hindawi Ltd, London, United Kingdom.
  • Macleod M Professor of Neurology and Translational Neuroscience, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
  • Pearl EJ Programme Manager - Experimental Design, NC3Rs, London, United Kingdom.
  • Petersen OH Director of the Academia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom.
  • Rawle F Director of Policy, Ethics and Governance, Medical Research Council, London, United Kingdom.
  • Reynolds P Biostatistician, Statistics in Anesthesiology Research (STAR) Core & Research Assistant Professor, Department of Anesthesiology College of Medicine, University of Florida, Gainesville, Florida, United States of America.
  • Rooney K Associate Professor, Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
  • Sena ES Stroke Association Kirby Laing Foundation Senior Non-Clinical Lecturer, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
  • Silberberg SD Director of Research Quality, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.
  • Steckler T Associate Director, BRQC Animal Welfare Strategy Lead, Janssen Pharmaceutica NV, Beerse, Belgium.
  • Würbel H Professor for Animal Welfare, Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
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  • 2020-07-16
Published in:
  • The Journal of physiology. - 2020
Physiology
English Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the 'ARRIVE Essential 10,' which constitutes the minimum requirement, and the 'Recommended Set,' which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.
Language
  • English
Open access status
bronze
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Persistent URL
https://folia.unifr.ch/global/documents/45646
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