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Acute Toxicity and Quality of Life After Dose-Intensified Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer After Prostatectomy: First Results of the Randomized Trial SAKK 09/10.
Journal article

Acute Toxicity and Quality of Life After Dose-Intensified Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer After Prostatectomy: First Results of the Randomized Trial SAKK 09/10.

  • Ghadjar P Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium. pirus.ghadjar@charite.de.
  • Hayoz S Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Bernhard J Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Zwahlen DR Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Hölscher T Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Gut P Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Guckenberger M Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Hildebrandt G Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Müller AC Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Plasswilm L Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Papachristofilou A Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Stalder L Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Biaggi-Rudolf C Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Sumila M Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Kranzbühler H Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Najafi Y Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Ost P Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Azinwi NC Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Reuter C Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Bodis S Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Kaouthar K Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Wust P Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Thalmann GN Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
  • Aebersold DM Pirus Ghadjar, Jürg Bernhard, George N. Thalmann, and Daniel M. Aebersold, Inselspital, Bern University Hospital, and University of Bern; Stefanie Hayoz, Lukas Stalder, and Christine Biaggi-Rudolf, Swiss Group for Clinical Cancer Research Coordinating Center; Jürg Bernhard, International Breast Cancer Study Group Coordinating Center, Bern; Daniel R. Zwahlen, Kantonsspital Graubünden, Chur; Philipp Gut, Kantonsspital Luzern, Luzern; Ludwig Plasswilm, Kantonsspital St Gallen, St Gallen; Alexandros Papachristofilou, University Hospital Basel, Basel; Marcin Sumila, Hirslanden Hospital Group, Zürich; Helmut Kranzbühler, Stadtspital Triemli, Zürich; Yousef Najafi, University Hospital Zürich, Zürich; Ngwa C. Azinwi, Istituto Oncologico della Svizzera Italiana, Bellinzona; Christiane Reuter, Kantonsspital Münsterlingen, Münsterlingen; Stephan Bodis, Kantonsspital Aarau, Aarau; Khanfir Kaouthar, Hôpital Valais, Sion, Switzerland; Pirus Ghadjar and Peter Wust, Charité Universitätsmedizin, Berlin; Tobias Hölscher, University Hospital Dresden, Dresden; Matthias Gluckenberger, University Hospital Würzburg, Würzburg; Guido Hildebrandt, University Hospital Rostock, Rostock; Arndt-Christian Müller, University Hospital Tübingen, Tübingen, Germany; and Piet Ost, Ghent University Hospital, Ghent, Belgium.
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  • 2015-11-04
Published in:
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 2015
Aged
Biomarkers, Tumor
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
Quality of Life
Radiotherapy Dosage
Radiotherapy, Conformal
Radiotherapy, Intensity-Modulated
Salvage Therapy
Self Report
Severity of Illness Index
Urination
Urination Disorders
English PURPOSE
Patients with biochemical failure (BF) after radical prostatectomy may benefit from dose-intensified salvage radiation therapy (SRT) of the prostate bed. We performed a randomized phase III trial assessing dose intensification.


PATIENTS AND METHODS
Patients with BF but without evidence of macroscopic disease were randomly assigned to either 64 or 70 Gy. Three-dimensional conformal radiation therapy or intensity-modulated radiation therapy/rotational techniques were used. The primary end point was freedom from BF. Secondary end points were acute toxicity according to the National Cancer Institute Common Terminology Criteria for Adverse Events (version 4.0) and quality of life (QoL) according to the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires C30 and PR25.


RESULTS
Three hundred fifty patients were enrolled between February 2011 and April 2014. Three patients withdrew informed consent, and three patients were not eligible, resulting in 344 patients age 48 to 75 years in the safety population. Thirty patients (8.7%) had grade 2 and two patients (0.6%) had grade 3 genitourinary (GU) baseline symptoms. Acute grade 2 and 3 GU toxicity was observed in 22 patients (13.0%) and one patient (0.6%), respectively, with 64 Gy and in 29 patients (16.6%) and three patients (1.7%), respectively, with 70 Gy (P = .2). Baseline grade 2 GI toxicity was observed in one patient (0.6%). Acute grade 2 and 3 GI toxicity was observed in 27 patients (16.0%) and one patient (0.6%), respectively, with 64 Gy, and in 27 patients (15.4%) and four patients (2.3%), respectively, with 70 Gy (P = .8). Changes in early QoL were minor. Patients receiving 70 Gy reported a more pronounced and clinically relevant worsening in urinary symptoms (mean difference in change score between arms, 3.6; P = .02).


CONCLUSION
Dose-intensified SRT was associated with low rates of acute grade 2 and 3 GU and GI toxicity. The impact of dose-intensified SRT on QoL was minor, except for a significantly greater worsening in urinary symptoms.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/45129
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