Journal article
Psychological Stress, Inflammation, and Coronary Heart Disease.
- Wirtz PH Biological Work and Health Psychology, Department of Psychology, University of Konstanz, Universitaetsstrasse 10, 78457, Constance, Baden-Wuerttemberg, Germany. petra.wirtz@uni-konstanz.de.
- von Känel R Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
- 2017-09-22
Published in:
- Current cardiology reports. - 2017
C-reactive protein
Coronary heart disease
Cytokines
Exhaustion
Inflammation
Inflammatory stress response
Interleukin
Intervention
Job burnout
Psychosocial stress
Biomarkers
Coronary Disease
Humans
Inflammation
Risk Factors
Stress, Psychological
English
PURPOSE OF REVIEW
In this review, we summarize evidence on the risk factor psychological stress in the context of coronary heart disease (CHD) in humans and explore the role of inflammation as a potential underlying mechanism.
RECENT FINDINGS
While chronic stress increases the risk of incident CHD and poor cardiovascular prognosis, acute emotional stress can trigger acute CHD events in vulnerable patients. Evidence supporting a potential role for inflammation as a promising biological mechanism comes from population-based studies showing associations between chronic stress and increased inflammation. Similarly, experimental studies demonstrate acute stress-induced increases in inflammatory markers and suggest modulatory potential for pharmacological and biobehavioral interventions. So far, studies investigating patients with cardiovascular disease are few and the full sequence of events from stress to inflammation to CHD remains to be established. Psychological stress is an independent CHD risk factor associated with increased inflammation. Although promising, causality needs to be further explored.
In this review, we summarize evidence on the risk factor psychological stress in the context of coronary heart disease (CHD) in humans and explore the role of inflammation as a potential underlying mechanism.
RECENT FINDINGS
While chronic stress increases the risk of incident CHD and poor cardiovascular prognosis, acute emotional stress can trigger acute CHD events in vulnerable patients. Evidence supporting a potential role for inflammation as a promising biological mechanism comes from population-based studies showing associations between chronic stress and increased inflammation. Similarly, experimental studies demonstrate acute stress-induced increases in inflammatory markers and suggest modulatory potential for pharmacological and biobehavioral interventions. So far, studies investigating patients with cardiovascular disease are few and the full sequence of events from stress to inflammation to CHD remains to be established. Psychological stress is an independent CHD risk factor associated with increased inflammation. Although promising, causality needs to be further explored.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s11886-017-0919-x
- PMID 28932967
- Persistent URL
- https://folia.unifr.ch/global/documents/44200
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