EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy.
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Pajno GB
Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy.
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Fernandez-Rivas M
Allergy Department, IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
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Arasi S
Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy.
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Roberts G
The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, UK.
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Akdis CA
Swiss Institute for Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
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Alvaro-Lozano M
Paediatric Allergy and Clinical Immunology Section, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.
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Beyer K
Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany.
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Bindslev-Jensen C
Department of Dermatology and Allergy Center, Odense Research Center for anaphylaxis, Odense, Denmark.
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Burks W
Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Ebisawa M
Department of Allergy, Clinical Research Center for Allergy & Rheumatology, Sagamihara National Hospital, Sagamihara, Japan.
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Eigenmann P
Medical School of the University of Geneva, University Hospitals of Geneva, Geneva, Switzerland.
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Knol E
Department of Immunology and Department of Dermatology & Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
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Nadeau KC
Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, Stanford University, Stanford, CA, USA.
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Poulsen LK
Allergy Clinic, Copenhagen University Hospital, Gentofte, Denmark.
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van Ree R
Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.
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Santos AF
Division of Asthma Allergy and Lung Biology, Department of Paediatric Allergy, King's College London, London, UK.
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du Toit G
Division of Asthma Allergy and Lung Biology, Department of Paediatric Allergy, King's College London, London, UK.
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Dhami S
Evidence-Based Health Care Ltd, Edinburgh, UK.
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Nurmatov U
Division of Population Medicine Neuadd Meirionnydd, School of Medicine, Cardiff University, Cardiff, UK.
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Boloh Y
EAACI Patient Organization Committee, Region de Mans, France.
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Makela M
Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
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O'Mahony L
Swiss Institute for Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
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Papadopoulos N
2nd Pediatric Clinic, Allergy, University of Athens, Athens, Greece.
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Sackesen C
Koç University Hospital, Istanbul, Turkey.
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Agache I
Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University Brasov, Brasov, Romania.
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Angier E
Sheffield Teaching Hospital, Sheffield, UK.
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Halken S
Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
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Jutel M
Wroclaw Medical University, Wroclaw, Poland.
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Lau S
Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany.
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Pfaar O
Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
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Ryan D
Allergy and Respiratory Research Group, Usher Institute of Population Health Sciences and Informatics, Medical School, University of Edinburgh, Edinburgh, UK.
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Sturm G
Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.
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Varga EM
Department of Paediatric and Adolescent Medicine, Respiratory and Allergic Disease Division, Medical University of Graz, Graz, Austria.
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van Wijk RG
Section of Allergology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
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Sheikh A
Allergy and Respiratory Research Group, Usher Institute of Population Health Sciences and Informatics, Medical School, University of Edinburgh, Edinburgh, UK.
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Muraro A
Department of Women and Child Health, Food Allergy Referral Centre Veneto Region, Padua General University Hospital, Padua, Italy.
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English
Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task Force on Allergen Immunotherapy for IgE-mediated Food Allergy, aims to provide evidence-based recommendations for active treatment of IgE-mediated food allergy with FA-AIT. Immunotherapy relies on the delivery of gradually increasing doses of specific allergen to increase the threshold of reaction while on therapy (also known as desensitization) and ultimately to achieve post-discontinuation effectiveness (also known as tolerance or sustained unresponsiveness). Oral FA-AIT has most frequently been assessed: here, the allergen is either immediately swallowed (OIT) or held under the tongue for a period of time (SLIT). Overall, trials have found substantial benefit for patients undergoing either OIT or SLIT with respect to efficacy during treatment, particularly for cow's milk, hen's egg, and peanut allergies. A benefit post-discontinuation is also suggested, but not confirmed. Adverse events during FA-AIT have been frequently reported, but few subjects discontinue FA-AIT as a result of these. Taking into account the current evidence, FA-AIT should only be performed in research centers or in clinical centers with an extensive experience in FA-AIT. Patients and their families should be provided with information about the use of FA-AIT for IgE-mediated food allergy to allow them to make an informed decision about the therapy.
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bronze
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https://folia.unifr.ch/global/documents/41763
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