Knowledge gaps in oncoplastic breast surgery.
- Weber WP Breast Center, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Surgery, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: walter.weber@usb.ch.
- Morrow M Breast Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- Boniface J Department of Surgery, Capio Saint Göran's Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
- Pusic A Division of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
- Montagna G Breast Center, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Gynecology and Obstetrics, University Hospital Basel and University of Basel, Basel, Switzerland; Breast Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- Kappos EA Breast Center, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Surgery, University Hospital Basel and University of Basel, Basel, Switzerland.
- Ritter M Breast Center, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Surgery, University Hospital Basel and University of Basel, Basel, Switzerland.
- Haug M Breast Center, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Surgery, University Hospital Basel and University of Basel, Basel, Switzerland.
- Kurzeder C Breast Center, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Gynecology and Obstetrics, University Hospital Basel and University of Basel, Basel, Switzerland.
- Saccilotto R Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
- Schulz A Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
- Benson J Cambridge Breast Unit, Addenbrooke's Hospital Cambridge, Cambridge, UK; School of Medicine, Anglia Ruskin University, Cambridge, UK.
- Fitzal F Department of Surgery and Breast Health Center, Comprehensive Cancer Center, Medical University Vienna, Vienna, Austria.
- Matrai Z Department of Breast and Sarcoma Surgery, National Institute of Oncology, Budapest, Hungary.
- Shaw J Patient Advocacy Group, Oncoplastic Breast Consortium, Basel, Switzerland.
- Peeters MV Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands.
- Potter S Centre for Surgical Research, Bristol Medical School, Bristol, UK; Bristol Breast Care Centre, North Bristol National Health Service Trust, Bristol, UK.
- Heil J Department of Obstetrics and Gynecology, University Breast Unit, University Women's Hospital Heidelberg, Heidelberg, Germany.
- 2020-08-08
Published in:
- The Lancet. Oncology. - 2020
English
The aims of the Oncoplastic Breast Consortium initiative were to identify important knowledge gaps in the field of oncoplastic breast-conserving surgery and nipple-sparing or skin-sparing mastectomy with immediate breast reconstruction, and to recommend appropriate research strategies to address these gaps. A total of 212 surgeons and 26 patient advocates from 55 countries prioritised the 15 most important knowledge gaps from a list of 38 in two electronic Delphi rounds. An interdisciplinary panel of the Oncoplastic Breast Consortium consisting of 63 stakeholders from 20 countries obtained consensus during an in-person meeting to select seven of these 15 knowledge gaps as research priorities. Three key recommendations emerged from the meeting. First, the effect of oncoplastic breast-conserving surgery on quality of life and the optimal type and timing of reconstruction after nipple-sparing or skin-sparing mastectomy with planned radiotherapy should be addressed by prospective cohort studies at an international level. Second, the role of adjunctive mesh and the positioning of implants during implant-based breast reconstruction should ideally be investigated by randomised controlled trials of pragmatic design. Finally, the BREAST-Q questionnaire is a suitable tool to assess primary outcomes in these studies, but other metrics to measure patient-reported outcomes should be systematically evaluated and quality indicators of surgical morbidity should be further assessed.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/S1470-2045(20)30084-X
- PMID 32758475
- Persistent URL
- https://folia.unifr.ch/global/documents/40026
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