Association of socioeconomic status with inflammatory markers: a two cohort comparison.
- Fraga S EPIUnit- Institute of Public Health - University of Porto, Porto, Portugal. Electronic address: silfraga@med.up.pt.
- Marques-Vidal P Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
- Vollenweider P Department of Medicine, Internal Medicine, CHUV and Faculty of Biology and Medicine, Lausanne, Switzerland.
- Waeber G Department of Medicine, Internal Medicine, CHUV and Faculty of Biology and Medicine, Lausanne, Switzerland.
- Guessous I Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland; Unit of Population Epidemiology, Geneva University Hospital, Geneva, Switzerland; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, USA.
- Paccaud F Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
- Barros H EPIUnit- Institute of Public Health - University of Porto, Porto, Portugal.
- Stringhini S Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
- 2014-12-09
Published in:
- Preventive medicine. - 2015
Inflammation
Portugal
Socioeconomic status
Switzerland
Adult
Aged
Biomarkers
C-Reactive Protein
Chronic Disease
Cohort Studies
Educational Status
Female
Fibrinogen
Health Behavior
Humans
Inflammation
Interleukin-6
Leukocytes
Logistic Models
Male
Middle Aged
Portugal
Risk Factors
Smoking
Social Class
Socioeconomic Factors
Surveys and Questionnaires
Switzerland
Tumor Necrosis Factor-alpha
English
OBJECTIVE
To assess the association between socioeconomic status (SES) and inflammatory markers using two different European population samples.
METHODS
We used data from the CoLaus (N=6412, Lausanne, Switzerland) and EPIPorto (N=1205, Porto, Portugal) studies. Education and occupational position were used as indicators of socioeconomic status (SES). High-sensitivity C-reactive protein (hs-CRP) was available for both cohorts. Interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) were available in CoLaus; leukocyte count and fibrinogen in EPIPorto.
RESULTS
We showed that low SES was significantly associated with high inflammation in both studies. We also showed that behavioural factors contributed the most to SES differences in inflammation. In both studies the larger difference between the lowest and the highest SES was observed for hs-CRP. In the Swiss sample, a linear association between education and hs-CRP persisted after adjustment for all mediating factors and confounders considered (p for linear trend <0.001).
CONCLUSION
Large social differences exist in inflammatory activity, in part independently from demographic and behavioural factors, chronic conditions and medication use. SES differences in inflammation are also similar in countries with different underlying socioeconomic conditions.
To assess the association between socioeconomic status (SES) and inflammatory markers using two different European population samples.
METHODS
We used data from the CoLaus (N=6412, Lausanne, Switzerland) and EPIPorto (N=1205, Porto, Portugal) studies. Education and occupational position were used as indicators of socioeconomic status (SES). High-sensitivity C-reactive protein (hs-CRP) was available for both cohorts. Interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) were available in CoLaus; leukocyte count and fibrinogen in EPIPorto.
RESULTS
We showed that low SES was significantly associated with high inflammation in both studies. We also showed that behavioural factors contributed the most to SES differences in inflammation. In both studies the larger difference between the lowest and the highest SES was observed for hs-CRP. In the Swiss sample, a linear association between education and hs-CRP persisted after adjustment for all mediating factors and confounders considered (p for linear trend <0.001).
CONCLUSION
Large social differences exist in inflammatory activity, in part independently from demographic and behavioural factors, chronic conditions and medication use. SES differences in inflammation are also similar in countries with different underlying socioeconomic conditions.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.ypmed.2014.11.031
- PMID 25482420
- Persistent URL
- https://folia.unifr.ch/global/documents/38891
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