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2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp(3))-H Functionalization of Trifluoroacetimidoyl Chlorides.
Journal article

2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp(3))-H Functionalization of Trifluoroacetimidoyl Chlorides.

  • Pedroni J Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland.
  • Cramer N Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland.
  • 2016-04-08
Published in:
  • Organic letters. - 2016
Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry
English Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp(3))-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from anilines. The cyclization operates with catalyst loadings as low as 1 mol % and accommodates a variety of substituents.
Language
  • English
Open access status
closed
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Persistent URL
https://folia.unifr.ch/global/documents/37894
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