Journal article
Tenascin-W: an extracellular matrix protein associated with osteogenesis and cancer.
- Martina E Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
- Chiquet-Ehrismann R
- Brellier F
- 2010-06-15
Published in:
- The international journal of biochemistry & cell biology. - 2010
English
Tenascin-W was the last member of a family of four large extracellular matrix glycoproteins to be discovered. The original member of the tenascin family, tenascin-C, has been widely studied due to its association with asthma, fibrosis, infection, inflammation and cancer. Recent studies report multiple common features between tenascin-W and tenascin-C in terms of structure, expression and function, especially in the context of tumorigenesis. Furthermore, specific functions for tenascin-W in osteogenesis have been revealed. This review presents an update on our current knowledge concerning tenascin-W and discusses potential medical applications of this cancer-enriched extracellular matrix protein.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.biocel.2010.06.004
- PMID 20541035
- Persistent URL
- https://folia.unifr.ch/global/documents/37280
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