Infliximab in pediatric rheumatology patients: a retrospective analysis of infusion reactions and severe adverse events during 2246 infusions over 12 years.
Journal article

Infliximab in pediatric rheumatology patients: a retrospective analysis of infusion reactions and severe adverse events during 2246 infusions over 12 years.

  • Aeschlimann FA From the Department of Rheumatology, University Children's Hospital, Zurich; Ostschweizer Kinderspital, St. Gallen; and Department of Pediatrics, Kantonsspital Winterthur, Switzerland.F.A. Aeschlimann, MD, rheumatology fellow; K.D. Hofer, medical student; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist; S. Schroeder, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children's Hospital; R. Lauener, MD, professor, head of pediatric department, Ostschweizer Kinderspital; R.K. Saurenmann, MD, head of pediatric department, Department of Rheumatology, University Children's Hospital, and Department of Pediatrics, Kantonsspital Winterthur.
  • Hofer KD From the Department of Rheumatology, University Children's Hospital, Zurich; Ostschweizer Kinderspital, St. Gallen; and Department of Pediatrics, Kantonsspital Winterthur, Switzerland.F.A. Aeschlimann, MD, rheumatology fellow; K.D. Hofer, medical student; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist; S. Schroeder, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children's Hospital; R. Lauener, MD, professor, head of pediatric department, Ostschweizer Kinderspital; R.K. Saurenmann, MD, head of pediatric department, Department of Rheumatology, University Children's Hospital, and Department of Pediatrics, Kantonsspital Winterthur.
  • Cannizzaro Schneider E From the Department of Rheumatology, University Children's Hospital, Zurich; Ostschweizer Kinderspital, St. Gallen; and Department of Pediatrics, Kantonsspital Winterthur, Switzerland.F.A. Aeschlimann, MD, rheumatology fellow; K.D. Hofer, medical student; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist; S. Schroeder, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children's Hospital; R. Lauener, MD, professor, head of pediatric department, Ostschweizer Kinderspital; R.K. Saurenmann, MD, head of pediatric department, Department of Rheumatology, University Children's Hospital, and Department of Pediatrics, Kantonsspital Winterthur.
  • Schroeder S From the Department of Rheumatology, University Children's Hospital, Zurich; Ostschweizer Kinderspital, St. Gallen; and Department of Pediatrics, Kantonsspital Winterthur, Switzerland.F.A. Aeschlimann, MD, rheumatology fellow; K.D. Hofer, medical student; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist; S. Schroeder, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children's Hospital; R. Lauener, MD, professor, head of pediatric department, Ostschweizer Kinderspital; R.K. Saurenmann, MD, head of pediatric department, Department of Rheumatology, University Children's Hospital, and Department of Pediatrics, Kantonsspital Winterthur.
  • Lauener R From the Department of Rheumatology, University Children's Hospital, Zurich; Ostschweizer Kinderspital, St. Gallen; and Department of Pediatrics, Kantonsspital Winterthur, Switzerland.F.A. Aeschlimann, MD, rheumatology fellow; K.D. Hofer, medical student; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist; S. Schroeder, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children's Hospital; R. Lauener, MD, professor, head of pediatric department, Ostschweizer Kinderspital; R.K. Saurenmann, MD, head of pediatric department, Department of Rheumatology, University Children's Hospital, and Department of Pediatrics, Kantonsspital Winterthur.
  • Saurenmann RK From the Department of Rheumatology, University Children's Hospital, Zurich; Ostschweizer Kinderspital, St. Gallen; and Department of Pediatrics, Kantonsspital Winterthur, Switzerland.F.A. Aeschlimann, MD, rheumatology fellow; K.D. Hofer, medical student; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist; S. Schroeder, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children's Hospital; R. Lauener, MD, professor, head of pediatric department, Ostschweizer Kinderspital; R.K. Saurenmann, MD, head of pediatric department, Department of Rheumatology, University Children's Hospital, and Department of Pediatrics, Kantonsspital Winterthur. traudel.saurenmann@kispi.uzh.ch.
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  • 2014-05-17
Published in:
  • The Journal of rheumatology. - 2014
English OBJECTIVE
To describe infusion reactions (IR) and severe adverse events (SAE) associated with infliximab (IFX) in pediatric patients with rheumatologic and ocular inflammatory diseases in a real-world setting.


METHODS
This is a retrospective chart review of all patients treated with IFX at the pediatric rheumatology division of a university hospital between October 2000 and December 2012.


RESULTS
A total of 2446 IFX infusions were given to 82 patients (72% female). IR occurred in 46 infusions (2%) of 14 patients (17%) after a mean IFX treatment time of 340 days (range 41-780); 9/14 patients (64%) experienced repeated IR. IR were classified as mild (26%), moderate (74%), or severe (0%). Indications for IFX were arthritis (60%), uveitis (20%), arthritis and uveitis (13%), and other inflammatory diseases (5%). The most common clinical symptoms were respiratory signs (72%), cutaneous manifestations (69%), and malaise (61%). In 6/14 patients (43%) with IR, IFX was discontinued: 4 patients because of repeated IR and 2 patients wished to stop treatment immediately following a mild IR. The other 8/14 patients (57%) received premedication with high-dose antihistamine (100%), corticosteroids (75%), and IFX dose increase (75%) and continued IFX treatment for a mean followup period of 146 weeks (range 26-537) after the first IR. We observed severe infections in 5/82 patients (6%); other SAE were rare.


CONCLUSION
Mild and moderate IR occurred in 17% of our patients. Treatment with antihistamines and methylprednisolone, and increasing the IFX dose, allowed continued treatment despite IR in > 50% of patients. Other SAE were infrequent.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/35805
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