Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Journal article

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.

  • Surendran P British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Feofanova EV Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Lahrouchi N Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Ntalla I William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Karthikeyan S British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Cook J Department of Biostatistics, University of Liverpool, Liverpool, UK.
  • Chen L British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Mifsud B William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Yao C Framingham Heart Study, Framingham, MA, USA.
  • Kraja AT Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
  • Cartwright JH William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Hellwege JN Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Giri A Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Tragante V Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Thorleifsson G deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Liu DJ Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
  • Prins BP British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Stewart ID MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Cabrera CP William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Eales JM Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
  • Akbarov A Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
  • Auer PL Joseph J Zilber School of Public Health, University of Wisconsin, Milwaukee, WI, USA.
  • Bielak LF Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
  • Bis JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Braithwaite VS MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Brody JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Daw EW Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
  • Warren HR William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Drenos F Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
  • Nielsen SF Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  • Faul JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
  • Fauman EB Internal Medicine Research Unit, Pfizer, Cambridge, MA, USA.
  • Fava C Department of Medicine, University of Verona, Verona, Italy.
  • Ferreira T The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
  • Foley CN British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Franceschini N Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  • Gao H Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Giannakopoulou O William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Giulianini F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Gudbjartsson DF deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Guo X Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Harris SE Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Havulinna AS Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
  • Helgadottir A deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Huffman JE MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
  • Hwang SJ Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kanoni S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Kontto J Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Larson MG Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
  • Li-Gao R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Lindström J Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Lotta LA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Lu Y The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Luan J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Mahajan A Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Malerba G Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
  • Masca NGD Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Mei H Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA.
  • Menni C Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Mook-Kanamori DO Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Mosen-Ansorena D Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Müller-Nurasyid M Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Paré G Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Paul DS British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Perola M Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Poveda A Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
  • Rauramaa R Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Richard M Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Richardson TG MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Sepúlveda N Department of Infection Biology, Faculty of Tropical and Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.
  • Sim X Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Smith AV Icelandic Heart Association, Kopavogur, Iceland.
  • Smith JA Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
  • Staley JR British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Stanáková A University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Sulem P deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Thériault S Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Thorsteinsdottir U deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Trompet S Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
  • Varga TV Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
  • Velez Edwards DR Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Tennessee Valley Health Systems VA, Nashville, TN, USA.
  • Veronesi G Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Weiss S Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.
  • Willems SM MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Yao J Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Young R British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Yu B Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Zhang W Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Zhao JH British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Zhao W Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
  • Zhao W Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
  • Evangelou E Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Aeschbacher S Division of Cardiology, University Hospital, Basel, Switzerland.
  • Asllanaj E Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Blankenberg S DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Bonnycastle LL Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
  • Bork-Jensen J Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Brandslund I Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
  • Braund PS Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Burgess S British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Cho K Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Christensen C Medical Department, Lillebaelt Hospital, Vejle, Denmark.
  • Connell J University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
  • Mutsert R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Dominiczak AF Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
  • Dörr M DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Eiriksdottir G Icelandic Heart Association, Kopavogur, Iceland.
  • Farmaki AE Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
  • Gaziano JM Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Grarup N Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Grove ML Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Hallmans G Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
  • Hansen T Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Have CT Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Heiss G Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  • Jørgensen ME Steno Diabetes Center, Copenhagen, Gentofte, Denmark.
  • Jousilahti P Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Kajantie E Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Kamat M British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Käräjämäki A Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.
  • Karpe F Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Koistinen HA Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Kovesdy CP Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA.
  • Kuulasmaa K Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Laatikainen T Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Lannfelt L Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
  • Lee IT Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Lee WJ Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Linneberg A George Washington University School of Medicine and Health Sciences, Washington DC, USA.
  • Martin LW Department of Public health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France.
  • Moitry M The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Nadkarni G Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Neville MJ Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
  • Palmer CNA Epidemiology Branch, NHLBI, Bethesda, MD, USA.
  • Papanicolaou GJ Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Pedersen O British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Peters J International Centre for Circulatory Health, Imperial College London, London, UK.
  • Poulter N Centre for Non-Communicable Diseases, Karachi, Pakistan.
  • Rasheed A Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  • Rasmussen KL Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Rayner NW Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Mägi R Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
  • Renström F DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Rettig R Division of Cardiovascular Sciences, NHLBI, Bethesda, MD, USA.
  • Rossouw J Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
  • Schreiner PJ National Heart and Lung Institute, Imperial College London, London, UK.
  • Sever PS Department of Family Medicine, University of Iceland, Reykjavik, Iceland.
  • Sigurdsson EL Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
  • Skaaby T Department of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
  • Sun YV Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Sundstrom J deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Thorgeirsson G Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Esko T Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
  • Trabetti E VA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Tsao PS Folkhälsan Research Centre, Helsinki, Finland.
  • Tuomi T Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
  • Turner ST Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Tzoulaki I Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.
  • Vaartjes I Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Vergnaud AC Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Willer CJ Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
  • Wilson PWF Department of Public Health, Aarhus University, Aarhus, Denmark.
  • Witte DR British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Yonova-Doing E Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Zhang H International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Aliya N Department of Medicine, Lund University, Malmö, Sweden.
  • Almgren P Univ Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
  • Amouyel P Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Asselbergs FW William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Barnes MR Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
  • Blakemore AI Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Boehnke M Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.
  • Bots ML The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bottinger EP Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Buring JE Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Chambers JC Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Chen YI British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Chowdhury R Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Conen D Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
  • Correa A MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Davey Smith G University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
  • Boer RA Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Deary IJ Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
  • Dedoussis G William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Deloukas P British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Di Angelantonio E Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Elliott P DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Felix SB Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Ferrières J Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
  • Ford I Institute of Reproductive & Developmental Biology, Imperial College London, London, UK.
  • Fornage M Centre for Non-Communicable Diseases, Karachi, Pakistan.
  • Franks PW Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
  • Franks S MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Frossard P Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
  • Gambaro G Icelandic Heart Association, Kopavogur, Iceland.
  • Gaunt TR Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA.
  • Groop L MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
  • Gudnason V MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.
  • Harris TB Institute of Biomedicine, Medical Research Center (MRC), University of Oulu, and University Hospital Oulu, Oulu, Finland.
  • Hayward C Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Hennig BJ Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Herzig KH Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
  • Ingelsson E Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Tuomilehto J Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
  • Järvelin MR Centre for Public Health, Queens University Belfast, Belfast, UK.
  • Jukema JW National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.
  • Kardia SLR Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
  • Kee F Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA.
  • Kooner JS Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Kooperberg C The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Launer LJ National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh.
  • Lind L Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Loos RJF Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Majumder AAS Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
  • Laakso M Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
  • McCarthy MI The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
  • Melander O Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  • Mohlke KL Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
  • Murray AD University of Glasgow, Glasgow, UK.
  • Nordestgaard BG Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Orho-Melander M Department of Medicine, Columbia University Medical Center, New York, NY, USA.
  • Packard CJ Department of Public Health, University of Split School of Medicine, Split, Croatia.
  • Padmanabhan S Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
  • Palmas W MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.
  • Polasek O Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
  • Porteous DJ MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Prentice AM Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Province MA Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Relton CL Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.
  • Rice K Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Ridker PM Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Rolandsson O Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, UK.
  • Rosendaal FR Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Rotter JI Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Rudan I Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
  • Salomaa V Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Samani NJ Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
  • Sattar N National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.
  • Sheu WH Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Smith BH Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Soranzo N Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Spector TD Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Starr JM Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Sebert S MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Taylor KD National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK.
  • Lakka TA University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
  • Timpson NJ University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
  • Tobin MD Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
  • van der Harst P Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • van der Meer P Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.
  • Ramachandran VS Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
  • Verweij N Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Virtamo J Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Völker U MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Weir DR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Zeggini E Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
  • Charchar FJ British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Wareham NJ British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Langenberg C Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
  • Tomaszewski M deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Butterworth AS VA Tennessee Valley Healthcare System, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Caulfield MJ Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Danesh J Boston University School of Public Health, Boston, MA, USA.
  • Edwards TL Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Holm H Department of Biostatistics, University of Liverpool, Liverpool, UK.
  • Hung AM Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Lindgren CM VA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Liu C Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Manning AK British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Morris AP deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
  • Morrison AC Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • O'Donnell CJ Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Psaty BM Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
  • Saleheen D Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Stefansson K William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. PBMunroe@qmul.ac.uk.
  • Boerwinkle E British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. JMMHowson@gmail.com.
  • Chasman DI
  • Levy D
  • Newton-Cheh C
  • Munroe PB
  • Howson JMM
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  • 2020-11-24
Published in:
  • Nature genetics. - 2020
English Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10-8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.
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https://folia.unifr.ch/global/documents/35521
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