Journal article
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
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Surendran P
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Feofanova EV
Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
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Lahrouchi N
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
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Ntalla I
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Karthikeyan S
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Cook J
Department of Biostatistics, University of Liverpool, Liverpool, UK.
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Chen L
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Mifsud B
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Yao C
Framingham Heart Study, Framingham, MA, USA.
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Kraja AT
Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
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Cartwright JH
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Hellwege JN
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
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Giri A
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
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Tragante V
Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
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Thorleifsson G
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Liu DJ
Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
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Prins BP
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Stewart ID
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Cabrera CP
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Eales JM
Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
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Akbarov A
Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
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Auer PL
Joseph J Zilber School of Public Health, University of Wisconsin, Milwaukee, WI, USA.
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Bielak LF
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
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Bis JC
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
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Braithwaite VS
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Brody JA
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
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Daw EW
Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
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Warren HR
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Drenos F
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
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Nielsen SF
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
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Faul JD
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
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Fauman EB
Internal Medicine Research Unit, Pfizer, Cambridge, MA, USA.
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Fava C
Department of Medicine, University of Verona, Verona, Italy.
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Ferreira T
The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
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Foley CN
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Franceschini N
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
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Gao H
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Giannakopoulou O
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Giulianini F
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
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Gudbjartsson DF
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Guo X
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
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Harris SE
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
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Havulinna AS
Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
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Helgadottir A
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Huffman JE
MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
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Hwang SJ
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
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Kanoni S
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Kontto J
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Larson MG
Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
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Li-Gao R
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
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Lindström J
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Lotta LA
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Lu Y
The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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Luan J
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Mahajan A
Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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Malerba G
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
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Masca NGD
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
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Mei H
Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA.
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Menni C
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
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Mook-Kanamori DO
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
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Mosen-Ansorena D
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Müller-Nurasyid M
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
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Paré G
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
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Paul DS
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Perola M
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Poveda A
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
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Rauramaa R
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
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Richard M
Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
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Richardson TG
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
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Sepúlveda N
Department of Infection Biology, Faculty of Tropical and Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.
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Sim X
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
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Smith AV
Icelandic Heart Association, Kopavogur, Iceland.
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Smith JA
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
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Staley JR
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Stanáková A
University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
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Sulem P
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Thériault S
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
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Thorsteinsdottir U
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Trompet S
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
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Varga TV
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
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Velez Edwards DR
Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Tennessee Valley Health Systems VA, Nashville, TN, USA.
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Veronesi G
Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
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Weiss S
Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.
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Willems SM
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Yao J
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
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Young R
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Yu B
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
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Zhang W
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Zhao JH
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Zhao W
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
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Zhao W
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
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Evangelou E
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Aeschbacher S
Division of Cardiology, University Hospital, Basel, Switzerland.
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Asllanaj E
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
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Blankenberg S
DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
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Bonnycastle LL
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
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Bork-Jensen J
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Brandslund I
Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
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Braund PS
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
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Burgess S
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Cho K
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
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Christensen C
Medical Department, Lillebaelt Hospital, Vejle, Denmark.
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Connell J
University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
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Mutsert R
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
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Dominiczak AF
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
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Dörr M
DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
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Eiriksdottir G
Icelandic Heart Association, Kopavogur, Iceland.
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Farmaki AE
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
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Gaziano JM
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
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Grarup N
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Grove ML
Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
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Hallmans G
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
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Hansen T
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Have CT
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Heiss G
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
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Jørgensen ME
Steno Diabetes Center, Copenhagen, Gentofte, Denmark.
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Jousilahti P
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Kajantie E
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Kamat M
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Käräjämäki A
Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.
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Karpe F
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
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Koistinen HA
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Kovesdy CP
Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA.
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Kuulasmaa K
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Laatikainen T
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Lannfelt L
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
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Lee IT
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
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Lee WJ
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
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Linneberg A
George Washington University School of Medicine and Health Sciences, Washington DC, USA.
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Martin LW
Department of Public health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France.
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Moitry M
The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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Nadkarni G
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
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Neville MJ
Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
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Palmer CNA
Epidemiology Branch, NHLBI, Bethesda, MD, USA.
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Papanicolaou GJ
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Pedersen O
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Peters J
International Centre for Circulatory Health, Imperial College London, London, UK.
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Poulter N
Centre for Non-Communicable Diseases, Karachi, Pakistan.
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Rasheed A
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
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Rasmussen KL
Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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Rayner NW
Institute of Genomics, University of Tartu, Tartu, Estonia.
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Mägi R
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
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Renström F
DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
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Rettig R
Division of Cardiovascular Sciences, NHLBI, Bethesda, MD, USA.
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Rossouw J
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
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Schreiner PJ
National Heart and Lung Institute, Imperial College London, London, UK.
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Sever PS
Department of Family Medicine, University of Iceland, Reykjavik, Iceland.
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Sigurdsson EL
Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
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Skaaby T
Department of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
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Sun YV
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
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Sundstrom J
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Thorgeirsson G
Institute of Genomics, University of Tartu, Tartu, Estonia.
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Esko T
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
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Trabetti E
VA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
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Tsao PS
Folkhälsan Research Centre, Helsinki, Finland.
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Tuomi T
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
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Turner ST
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Tzoulaki I
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.
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Vaartjes I
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Vergnaud AC
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
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Willer CJ
Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
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Wilson PWF
Department of Public Health, Aarhus University, Aarhus, Denmark.
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Witte DR
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Yonova-Doing E
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
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Zhang H
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
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Aliya N
Department of Medicine, Lund University, Malmö, Sweden.
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Almgren P
Univ Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
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Amouyel P
Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
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Asselbergs FW
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Barnes MR
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
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Blakemore AI
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
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Boehnke M
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.
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Bots ML
The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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Bottinger EP
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
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Buring JE
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Chambers JC
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
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Chen YI
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Chowdhury R
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
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Conen D
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
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Correa A
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
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Davey Smith G
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
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Boer RA
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
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Deary IJ
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
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Dedoussis G
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Deloukas P
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Di Angelantonio E
Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
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Elliott P
DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
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Felix SB
Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
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Ferrières J
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
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Ford I
Institute of Reproductive & Developmental Biology, Imperial College London, London, UK.
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Fornage M
Centre for Non-Communicable Diseases, Karachi, Pakistan.
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Franks PW
Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
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Franks S
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
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Frossard P
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
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Gambaro G
Icelandic Heart Association, Kopavogur, Iceland.
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Gaunt TR
Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA.
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Groop L
MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.
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Gudnason V
MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.
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Harris TB
Institute of Biomedicine, Medical Research Center (MRC), University of Oulu, and University Hospital Oulu, Oulu, Finland.
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Hayward C
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
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Hennig BJ
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Herzig KH
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
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Ingelsson E
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
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Tuomilehto J
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
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Järvelin MR
Centre for Public Health, Queens University Belfast, Belfast, UK.
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Jukema JW
National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.
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Kardia SLR
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
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Kee F
Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA.
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Kooner JS
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
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Kooperberg C
The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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Launer LJ
National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh.
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Lind L
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
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Loos RJF
Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
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Majumder AAS
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
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Laakso M
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
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McCarthy MI
The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
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Melander O
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
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Mohlke KL
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
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Murray AD
University of Glasgow, Glasgow, UK.
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Nordestgaard BG
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
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Orho-Melander M
Department of Medicine, Columbia University Medical Center, New York, NY, USA.
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Packard CJ
Department of Public Health, University of Split School of Medicine, Split, Croatia.
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Padmanabhan S
Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
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Palmas W
MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.
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Polasek O
Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
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Porteous DJ
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
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Prentice AM
Department of Biostatistics, University of Washington, Seattle, WA, USA.
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Province MA
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
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Relton CL
Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.
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Rice K
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
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Ridker PM
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
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Rolandsson O
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, UK.
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Rosendaal FR
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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Rotter JI
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
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Rudan I
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
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Salomaa V
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
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Samani NJ
Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
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Sattar N
National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.
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Sheu WH
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
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Smith BH
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
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Soranzo N
Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
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Spector TD
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
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Starr JM
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
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Sebert S
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
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Taylor KD
National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK.
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Lakka TA
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
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Timpson NJ
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
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Tobin MD
Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
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van der Harst P
Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
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van der Meer P
Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.
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Ramachandran VS
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
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Verweij N
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Virtamo J
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
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Völker U
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Weir DR
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Zeggini E
Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
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Charchar FJ
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Wareham NJ
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Langenberg C
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
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Tomaszewski M
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Butterworth AS
VA Tennessee Valley Healthcare System, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
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Caulfield MJ
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
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Danesh J
Boston University School of Public Health, Boston, MA, USA.
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Edwards TL
Department of Medicine, Harvard Medical School, Boston, MA, USA.
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Holm H
Department of Biostatistics, University of Liverpool, Liverpool, UK.
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Hung AM
Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
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Lindgren CM
VA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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Liu C
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
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Manning AK
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
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Morris AP
deCODE genetics/Amgen, Inc, Reykjavik, Iceland.
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Morrison AC
Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
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O'Donnell CJ
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
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Psaty BM
Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.
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Saleheen D
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
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Stefansson K
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. PBMunroe@qmul.ac.uk.
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Boerwinkle E
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. JMMHowson@gmail.com.
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Chasman DI
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Levy D
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Newton-Cheh C
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Munroe PB
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Howson JMM
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English
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10-8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.
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closed
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https://folia.unifr.ch/global/documents/35521
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