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REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology.

  • Ripperger JA Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musée 5, 1700 Fribourg, Switzerland.
  • Albrecht U
  • 2012-05-23
Published in:
  • Cell research. - 2012
ARNTL Transcription Factors
Basic Helix-Loop-Helix Transcription Factors
CLOCK Proteins
Circadian Rhythm
Cryptochromes
E-Box Elements
Humans
Nerve Tissue Proteins
Nuclear Receptor Subfamily 1, Group D, Member 1
Period Circadian Proteins
Receptors, Cytoplasmic and Nuclear
Repressor Proteins
English A hallmark of the mammalian circadian timing system is synchronization of physiology and behavior, but when this synchronization is disturbed, chronic diseases such as metabolic syndrome and depression may develop. Three new studies show that nuclear receptors of the Rev-Erb family impact the circadian oscillator and its metabolic output and this can be modified with specific agonists. Hence, resynchronization of metabolic pathways by manipulation of the circadian oscillator using REV-ERB-specific agonists may represent a feasible therapeutic concept to target diseases rooted in a misaligned circadian system.
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  • English
Open access status
bronze
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https://folia.unifr.ch/global/documents/35001
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