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Actin, microtubules and focal adhesion dynamics during cell migration.
Journal article

Actin, microtubules and focal adhesion dynamics during cell migration.

  • Wehrle-Haller B Department of Pathology, Centre Médical Universitaire, 1 Rue Michel-Servet, 1211 4, Geneva, Switzerland. bernhard.wehrle-haller@medecine.unige.ch
  • Imhof BA
  • 2002-12-07
Published in:
  • The international journal of biochemistry & cell biology. - 2003
Actins
Animals
Biological Transport
Cell Adhesion
Cell Adhesion Molecules
Cell Membrane
Cell Movement
Cytoskeleton
Focal Adhesions
Humans
Microtubules
English Cell migration is a complex cellular behavior that results from the coordinated changes in the actin cytoskeleton and the controlled formation and dispersal of cell-substrate adhesion sites. While the actin cytoskeleton provides the driving force at the cell front, the microtubule network assumes a regulatory function in coordinating rear retraction. The polarity within migrating cells is further highlighted by the stationary behavior of focal adhesions in the front and their sliding in trailing ends. We discuss here the cross-talk of the actin cytoskeleton with the microtubule network and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/33278
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