Journal article
Wearable Biosensors for Monitoring Wound Healing
- Pasche, Stéphanie Centre Suisse d’Electronique et de Microtechnique SA (CSEM)
- Angeloni, Silvia Centre Suisse d’Electronique et de Microtechnique SA (CSEM)
- Ischer, Réal Centre Suisse d’Electronique et de Microtechnique SA (CSEM)
- Liley, Martha Centre Suisse d’Electronique et de Microtechnique SA (CSEM)
- Luprano, Jean Centre Suisse d’Electronique et de Microtechnique SA (CSEM)
- Voirin, Guy Centre Suisse d’Electronique et de Microtechnique SA (CSEM)
- 2008-9
Published in:
- Advances in Science and Technology. - Trans Tech Publications, Ltd.. - 2008, vol. 57, p. 80-87
English
Continuous health monitoring often requires hospitalization, which can become an
expensive and inconvenient choice for the patient. In this perspective, wearable sensors that allow in
situ biosensing constitute a very promising technology. This work aims to develop immunosensors
for continuous monitoring of the wound healing process, based on pH changes, as well as on the
concentrations of inflammatory proteins such as the C-reactive protein (CRP). Sensing principles
include the use of responsive hydrogels that swell in response to changes in the surroundings, and
the use of functional surfaces that specifically recognize the target protein. The detection principle is
based on an optical signal, using the evanescent field of light propagating along a waveguide,
probing refractive index changes. An optical sensing system that can be integrated in a wound
dressing patch has been designed, including a white light source (LED), and a spectrometer for
detection. The sensor was successfully tested in the laboratory with biological samples (blood
serum), demonstrating reversible pH measurements between pH 6-8, and detection of changes in the
concentration of CRP between 1 and 100 μg/ml. The sensor will later be integrated into wound
dressings or bandages, forming a sensing patch that is connected via optical fibres and electrical
wires to the detection system and power supply. This novel technology will be particularly valuable
in applications such as the supervision of skin grafts and ulcer treatments.
expensive and inconvenient choice for the patient. In this perspective, wearable sensors that allow in
situ biosensing constitute a very promising technology. This work aims to develop immunosensors
for continuous monitoring of the wound healing process, based on pH changes, as well as on the
concentrations of inflammatory proteins such as the C-reactive protein (CRP). Sensing principles
include the use of responsive hydrogels that swell in response to changes in the surroundings, and
the use of functional surfaces that specifically recognize the target protein. The detection principle is
based on an optical signal, using the evanescent field of light propagating along a waveguide,
probing refractive index changes. An optical sensing system that can be integrated in a wound
dressing patch has been designed, including a white light source (LED), and a spectrometer for
detection. The sensor was successfully tested in the laboratory with biological samples (blood
serum), demonstrating reversible pH measurements between pH 6-8, and detection of changes in the
concentration of CRP between 1 and 100 μg/ml. The sensor will later be integrated into wound
dressings or bandages, forming a sensing patch that is connected via optical fibres and electrical
wires to the detection system and power supply. This novel technology will be particularly valuable
in applications such as the supervision of skin grafts and ulcer treatments.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.4028/www.scientific.net/ast.57.80
- ISSN 1662-0356
- Persistent URL
- https://folia.unifr.ch/global/documents/32646
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