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Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors
Journal article

Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

  • Shapiguzov, Alexey ORCID Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russia
  • Vainonen, Julia P Viikki Plant Science Center, University of Helsinki, Helsinki, Finland
  • Hunter, Kerri ORCID Viikki Plant Science Center, University of Helsinki, Helsinki, Finland
  • Tossavainen, Helena Department of Chemistry, Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland
  • Tiwari, Arjun Department of Biochemistry / Molecular Plant Biology, University of Turku, Turku, Finland
  • Järvi, Sari Department of Biochemistry / Molecular Plant Biology, University of Turku, Turku, Finland
  • Hellman, Maarit Department of Chemistry, Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland
  • Aarabi, Fayezeh Max-Planck Institute for Molecular Plant Physiology, Potsdam, Germany
  • Alseekh, Saleh ORCID Center of Plant System Biology and Biotechnology, Plovdiv, Bulgaria
  • Wybouw, Brecht ORCID VIB Center for Plant Systems Biology, Ghent, Belgium
  • Van Der Kelen, Katrien VIB Center for Plant Systems Biology, Ghent, Belgium
  • Nikkanen, Lauri Department of Biochemistry / Molecular Plant Biology, University of Turku, Turku, Finland
  • Krasensky-Wrzaczek, Julia ORCID Viikki Plant Science Center, University of Helsinki, Helsinki, Finland
  • Sipari, Nina Viikki Metabolomics Unit, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
  • Keinänen, Markku Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland
  • Tyystjärvi, Esa Department of Biochemistry / Molecular Plant Biology, University of Turku, Turku, Finland
  • Rintamäki, Eevi Department of Biochemistry / Molecular Plant Biology, University of Turku, Turku, Finland
  • De Rybel, Bert ORCID VIB Center for Plant Systems Biology, Ghent, Belgium
  • Salojärvi, Jarkko ORCID Viikki Plant Science Center, University of Helsinki, Helsinki, Finland
  • Van Breusegem, Frank VIB Center for Plant Systems Biology, Ghent, Belgium
  • Fernie, Alisdair R Center of Plant System Biology and Biotechnology, Plovdiv, Bulgaria
  • Brosché, Mikael Institute of Technology, University of Tartu, Tartu, Estonia
  • Permi, Perttu Department of Biological and Environmental Science, Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland
  • Aro, Eva-Mari Department of Biochemistry / Molecular Plant Biology, University of Turku, Turku, Finland
  • Wrzaczek, Michael ORCID Viikki Plant Science Center, University of Helsinki, Helsinki, Finland
  • Kangasjärvi, Jaakko ORCID Viikki Plant Science Center, University of Helsinki, Helsinki, Finland
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  • 2019-2-15
Published in:
  • eLife. - eLife Sciences Publications, Ltd. - 2019, vol. 8
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
General Medicine
English Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.
Language
  • English
Open access status
gold
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Persistent URL
https://folia.unifr.ch/global/documents/31231
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