Journal article
Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor
- Cunha, Micael Rodrigues ORCID Department of Pharmacy
- Bhardwaj, Rajesh ORCID Switzerland
- Carrel, Aline Lucie ORCID Switzerland
- Lindinger, Sonja ORCID Austria
- Romanin, Christoph ORCID Austria
- Parise-Filho, Roberto ORCID Brazil
- Hediger, Matthias A. ORCID Switzerland
- Reymond, Jean-Louis ORCID Switzerland
- 2020
Published in:
- RSC Medicinal Chemistry. - Royal Society of Chemistry (RSC). - 2020, vol. 11, no. 9, p. 1032-1040
English
Natural product derived analogues were surveyed, and an oxygenated analog was identified as a potent and selective TRPV6 inhibitor, with high microsomal stability and low off-target effects.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1039/d0md00145g
- ISSN 2632-8682
- Persistent URL
- https://folia.unifr.ch/global/documents/30592
Statistics
Document views: 26
File downloads: