Regulation of blood pressure during long-term ouabain infusion in long-evans rats
csal
- Wang, Jingli Institute of Physiology, University of Fribourg, Fribourg, Switzerland
- Tempini, Aldo Institute of Physiology, University of Fribourg, Fribourg, Switzerland
- Schnyder, Bruno Institute of Physiology, University of Fribourg, Fribourg, Switzerland
- Montani, Jean-Pierre Institute of Physiology, University of Fribourg, Fribourg, Switzerland
-
1999
Published in:
- American Journal of Hypertension. - Oxford University Press. - 1999, vol. 12, no. S3, p. 423-426
English
We tested whether ouabain, an inhibitor of the sodium pump, can lead to chronic hypertension in Long-Evans rats using sensitive 24-h measurements of blood pressure. After a control week of vehicle isotonic saline infusion (14.4 mL/day), ouabain was infused intravenously at 30 μg/kg/day in intact (2K) and uninephrectomized (1K) Long-Evans rats for a total of 4 weeks. Although plasma ouabain concentration rose to 0.97 ± 0.15 nmol/L with ouabain infusion, mean arterial pressure did not change in either 2K (Δ = −0.6 ± 1.3 mm Hg) or 1K (Δ = −1.2 ± 0.7 mm Hg) rats. These data suggest that Long-Evans rats are insensitive to the hypertensive effects of ouabain. Am J Hypertens 1999;12:423-426 © 1999 American Journal of Hypertension, Ltd
- Collections
- Language
-
- English
- Classification
- Medicine
- License
-
License undefined© 1999 by the American Journal of Hypertension, Ltd.
- Identifiers
-
- RERO DOC 304408
- SWISSBIB (NATIONALLICENCE)oxford-10.1016/S0895-7061(00)86970-8
- DOI 10.1016/S0895-7061(00)86970-8
- Persistent URL
- https://folia.unifr.ch/global/documents/305887
Statistics
Document views: 21
File downloads:
- Fulltext: 0