Journal article
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Polyvinyl alcohol as a biocompatible alternative for the passivation of gold nanorods
Université de Fribourg
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Kinnear, Calum
Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
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Burnand, David
Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
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Clift, Martin J. D.
Adolphe Merkle Institut, Universität Freiburg, Switzerland
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Kilbinger, Andreas F. M.
Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
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Rothen-Rutishauser, Barbara
Adolphe Merkle Institut, Universität Freiburg, Switzerland
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Petri-Fink, Alke
Adolphe Merkle Institut, Universität Freiburg, Switzerland - Department Chemie, Universität Freiburg, Switzerland
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Published in:
- Angewandte Chemie International Edition. - 2014, vol. 53, no. 46, p. 12613–12617
English
The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor, polyvinyl acetate, which is then transformed into its hydrophilic analogue, polyvinyl alcohol. This polymer was chosen due to its well-established biocompatibility, tunable “stealth” properties, tunable hydrophobicity, and high degree of functionality. The biocompatibility of the functionalized GNRs was tested by exposing them to primary human blood monocyte derived macrophages; the advantages of tunable hydrophobicity were demonstrated with the long-term stable encapsulation of a model hydrophobic drug molecule.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Chimie
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Language
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Classification
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Chemistry
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/global/documents/304152
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