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pdf
Journal article

The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis

Université de Fribourg

  • Schnell, Anna Dept. of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Chappuis, Sylvie Dept. of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Schmutz, Isabelle Dept. of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Brai, Emanuele Dept. of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
  • Ripperger, Jürgen A. Dept. of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
  • Schaad, Olivier NCCR frontiers in Genetics, University of Geneva, Switzerland
  • Welzl, Hans Dept. of Anatomy, University of Zürich, Switzerland
  • Descombes, Patrick NCCR frontiers in Genetics, University of Geneva, Switzerland
  • Alberi, Lavinia Dept. of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
  • Albrecht, Urs Dept. of Biology, Unit of Biochemistry, University of Fribourg, Switzerland
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    16.06.2014
Published in:
  • PLoS ONE, 2014, vol. 9, no. 6, p. e99883
English The function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERBα. Loss of Rev-erbα manifested in memory and... Show more…
Language
  • English
Identifiers
Classification
Biology
Faculty
Faculté des sciences
Department
Médecine
License
License undefined
Persistent URL
https://folia.unifr.ch/global/documents/303789