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Journal article

Synthesis of a non-peptidic PET tracer designed for α5β1 integrin receptor

Université de Fribourg

  • Monaco, Alessandra Cyclotron Unit, University Hospital of Geneva, Switzerland - School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Switzerland
  • Michelin, Olivier Swiss Institute of Bioinformatics, University of Lausanne, Switzerland
  • Prior, John CHUV, Department of Nuclear Medicine, Lausanne, Switzerland
  • Rüegg, Curzio Faculty of Science, Department of Medicine, University of Fribourg, Switzerland
  • Scapozza, Leonardo School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Switzerland
  • Seimbille, Yann Cyclotron Unit, University Hospital of Geneva, Switzerland - School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Switzerland
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    01.03.2014
Published in:
  • Journal of labelled compounds & radiopharmaceuticals. - 2014, vol. 57, no. 5, p. 365-370
<em>α</em>₅<em>β</em>₁ integrin receptor
PET, 1-azide-2-[¹⁸F]fluoroethane
click chemistry
peptido-mimetic
English Arginine–glycine–aspartic acid (RGD)-containing peptides have been traditionally used as PET probes to noninvasively image angiogenesis, but recently, small selective molecules for <em>α</em>₅<em>β</em>₁ integrin receptor have been developed with promising results. Sixty-one antagonists were screened, and <em>tert</em>-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-fluoroethyl)-1H-1,2,3-triazol-4-... Show more…
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/303628