Synthesis of a non-peptidic PET tracer designed for α5β1 integrin receptor
Université de Fribourg
- Monaco, Alessandra Cyclotron Unit, University Hospital of Geneva, Switzerland - School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Switzerland
- Michelin, Olivier Swiss Institute of Bioinformatics, University of Lausanne, Switzerland
- Prior, John CHUV, Department of Nuclear Medicine, Lausanne, Switzerland
- Rüegg, Curzio Faculty of Science, Department of Medicine, University of Fribourg, Switzerland
- Scapozza, Leonardo School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Switzerland
- Seimbille, Yann Cyclotron Unit, University Hospital of Geneva, Switzerland - School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Switzerland
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01.03.2014
Published in:
- Journal of labelled compounds & radiopharmaceuticals, 2014, vol. 57, no. 5, p. 365-370
<em>α</em>₅<em>β</em>₁ integrin receptor
PET, 1-azide-2-[¹⁸F]fluoroethane
click chemistry
peptido-mimetic
English
Arginine–glycine–aspartic acid (RGD)-containing peptides have been traditionally used as PET probes to noninvasively image angiogenesis, but recently, small selective molecules for <em>α</em>₅<em>β</em>₁ integrin receptor have been developed with promising results. Sixty-one antagonists were screened, and <em>tert</em>-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-fluoroethyl)-1H-1,2,3-triazol-4-... Show more…
- Language
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- English
- Identifiers
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- Local identifier 210134 RERO DOC
- DOI 10.1002/jlcr.3190
- Classification
- Biology
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine
- License
- License undefined
- Persistent URL
- https://folia.unifr.ch/global/documents/303628