Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

• Aggarwal A Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Parai MK Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Shetty N Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Wallis D Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Woolhiser L Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
• Hastings C Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
• Dutta NK Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• Galaviz S Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Dhakal RC Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Shrestha R Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Wakabayashi S Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
• Walpole C Structure-guided Drug Discovery Coalition, SGC Toronto, ON, Canada.
• Matthews D Structure-guided Drug Discovery Coalition, SGC Toronto, ON, Canada.
• Floyd D Structure-guided Drug Discovery Coalition, SGC Toronto, ON, Canada.
• Scullion P Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.
• Riley J Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.
• Epemolu O Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.
• Norval S Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.
• Snavely T Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
• Robertson GT Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
• Rubin EJ Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
• Ioerger TR Department of Computer Science and Engineering, Texas A&M University, College Station, TX, USA.
• Sirgel FA NRF Centre of Excellence for Biomedical TB Research and the South African MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg, South Africa.
• van der Merwe R NRF Centre of Excellence for Biomedical TB Research and the South African MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg, South Africa.
• van Helden PD NRF Centre of Excellence for Biomedical TB Research and the South African MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg, South Africa.
• Keller P Institute of Medical Microbiology, National Center for Mycobacteria, University of Zurich, Zurich, Switzerland.
• Böttger EC Institute of Medical Microbiology, National Center for Mycobacteria, University of Zurich, Zurich, Switzerland.
• Karakousis PC Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• Lenaerts AJ Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
• Sacchettini JC Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA. Electronic address: sacchett@tamu.edu.

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Mycobacterium tuberculosis

Pks13 thioesterase domain

benzofuran inhibitors

crystal structure

polyketide synthase

structure-based drug discovery

Animals

Antitubercular Agents

Benzofurans

Cell Line

Drug Design

Drug Resistance, Bacterial

Female

Mice

Mice, Inbred BALB C

Models, Molecular

Mycobacterium tuberculosis

Piperidines

Specific Pathogen-Free Organisms

Tuberculosis