Polyethylenimine is a strong inhibitor of human papillomavirus and cytomegalovirus infection
Université de Fribourg
- Spoden, Gilles A. Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
- Besold, Katrin Institute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
- Krauter, Steffi Institute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
- Plachter, Bodo Institute for Virology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
- Hanik, Nils Department of Chemistry, University of Fribourg, Switzerland
- Kilbinger, Andreas F. M. Department of Chemistry, University of Fribourg, Switzerland
- Lambert, Carsten Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
- Florin, Luise Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
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03.10.2011
Published in:
- Antimicrobial Agents and Chemotherapy. - 2012, vol. 56, no. 15, p. 75-82
English
Polyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells with polyethylenimine blocked primary attachment of both viruses to cells, resulting in a significant reduction of infection. In addition, the dissemination of human cytomegalovirus in culture cells was efficiently reduced by recurrent administration of polyethylenimine. Polyethylenimine concentrations required for inhibition of human papillomavirus and cytomegalovirus did not cause any cytotoxic effects. Polyethylenimines and their derivatives may thus be attractive molecules for the development of antiviral microbicides.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 29029
- DOI 10.1128/AAC.05147-11
- Persistent URL
- https://folia.unifr.ch/global/documents/302422
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