Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.

• Nagaraja S Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
• Quezada MA Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
• Gillespie SM Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
• Arzt M Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
• Lennon JJ Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
• Woo PJ Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
• Hovestadt V Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
• Kambhampati M Research Center for Genetic Medicine, Children's National Health System, Washington, DC, USA.
• Filbin MG Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA, USA.
• Suva ML Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
• Nazarian J Research Center for Genetic Medicine, Children's National Health System, Washington, DC, USA; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Department of Oncology, University Children's Hospital, Zurich, Switzerland.
• Monje M Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: mmonje@stanford.edu.

Show more…

DIPG

H3.3

H3K27Ac

H3K27M

H3K27me3

PRC2

active enhancers

glioma

histone variant

oligodendrocyte precursor cell

Brain

Brain Neoplasms

Cellular Reprogramming

Diffuse Intrinsic Pontine Glioma

Enhancer Elements, Genetic

Epigenesis, Genetic

Epigenomics

Gene Expression Profiling

Gene Expression Regulation, Neoplastic

Glioma

Histones

Humans

Lysine

Mutation

Pons

Signal Transduction

Transcriptome