Texte intégral
Texte intégral
Journal article

Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes

Université de Fribourg

  • Schneiter, Roger Division of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
  • Brügger, Britta Biochemie-Zentrum der Universität Heidelberg, Universität Heidelberg, Germany
  • Amann, Clare M. Department of Medicinal Chemistry, The University of Utah, Salt Lake City, USA
  • Prestwich, Glenn D. Department of Medicinal Chemistry, The University of Utah, Salt Lake City, USA
  • Epand, Raquel F. Department of Biochemistry, McMaster University, Hamilton, Canada
  • Zellnig, Günther Institute of Plant Physiology, Karl-Franzens University Graz, Austria
  • Wieland, Felix T. Biochemie-Zentrum der Universität Heidelberg, Universität Heidelberg, Germany
  • Epand, Richard M. Department of Biochemistry, McMaster University, Hamilton, Canada
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    27.06.2004
Published in:
  • Biochemical Journal, 2004, vol. 381, no. 941-949
English Morphological analysis of a conditional yeast mutant in acetyl-CoA carboxylase acc1ts/mtr7, the rate-limiting enzyme of fatty acid synthesis, suggested that the synthesis of C₂₆ VLCFAs (very-long-chain fatty acids) is important for maintaining the structure and function of the nuclear membrane. To characterize this C₂₆-dependent pathway in more detail, we have now examined cells that are... Show more…
Language
  • English
Identifiers
Classification
Biology
Faculty
Faculté des sciences
Department
Médecine
License
License undefined
Persistent URL
https://folia.unifr.ch/global/documents/299789