Texte intégral
Texte intégral
Journal article

Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae

Université de Fribourg

  • Faergeman, Nils J. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Feddersen, Søren Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Christiansen, Janne K. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Larsen, Morten K. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Schneiter, Roger Division of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
  • Ungermann, Christian Biochemie-Zentrum Heidelberg, Germany
  • Mutenda, Kudzai Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Roepstroff, Peter Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Knudsen, Jens Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
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    19.04.2004
Published in:
  • Biochemical Journal, 2004, vol. 380, no. 907-918
English In the present study, we show that depletion of acyl-CoA-binding protein, Acb1p, in yeast affects ceramide levels, protein trafficking, vacuole fusion and structure. Vacuoles in Acb1p-depleted cells are multi-lobed, contain significantly less of the SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) Nyv1p, Vam3p and Vti1p, and are unable to fuse in vitro.... Show more…
Language
  • English
Identifiers
Classification
Medicine
Faculty
Faculté des sciences
Department
Médecine
License
License undefined
Persistent URL
https://folia.unifr.ch/global/documents/299779