Journal article

Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae

Université de Fribourg

  • Faergeman, Nils J. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Feddersen, Søren Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Christiansen, Janne K. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Larsen, Morten K. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Schneiter, Roger Division of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
  • Ungermann, Christian Biochemie-Zentrum Heidelberg, Germany
  • Mutenda, Kudzai Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Roepstroff, Peter Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
  • Knudsen, Jens Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
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    19.04.2004
Published in:
  • Biochemical Journal. - 2004, vol. 380, no. 907-918
English In the present study, we show that depletion of acyl-CoA-binding protein, Acb1p, in yeast affects ceramide levels, protein trafficking, vacuole fusion and structure. Vacuoles in Acb1p-depleted cells are multi-lobed, contain significantly less of the SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) Nyv1p, Vam3p and Vti1p, and are unable to fuse in vitro.... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/299779