Texte intégral
Texte intégral
Journal article

Temporal dissection of Bax-induced events leading to fission of the single mitochondrion in Trypanosoma brucei

Université de Fribourg

  • Crausaz Esseiva, Anne Zoology, Department of Biology, University of Fribourg, Switzerland
  • Chanez, Anne-Laure Zoology, Department of Biology, University of Fribourg, Switzerland
  • Bochud-Allemann, Natacha Zoology, Department of Biology, University of Fribourg, Switzerland
  • Martinou, Jean-Claude Departement de Biologie Cellulaire, Sciences III, Genève, Switzerland
  • Hemphill, Andrew Institute of Parasitology, University of Bern, Switzerland
  • Schneider, André Zoology, Department of Biology, University of Fribourg, Switzerland
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    13.02.2004
Published in:
  • EMBO reports, 2004, vol. 5, no. 268-273
English The protozoan Trypanosoma brucei has a single mitochondrion and lacks an apoptotic machinery. Here we show that expression of the proapoptotic protein Bax in T. brucei causes the release of cytochrome c, the depolarization of the mitochondrial membrane potential and mitochondrial fission. However, in contrast to mammalian cells, the three events are temporally well separated. The release of... Show more…
Language
  • English
Identifiers
Classification
Biology
Faculty
Faculté des sciences
Department
Biologie
License
License undefined
Persistent URL
https://folia.unifr.ch/global/documents/299564