Texte intégral
Texte intégral
Journal article

Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line

Université de Fribourg

  • Wicky, Chantal Department of Biology, University of Fribourg, Switzerland
  • Alpi, Arno Max Planck Institute for Biochemistry, Martinsried, Germany
  • Passannante, Myriam Department of Biology, University of Fribourg, Switzerland
  • Rose, Ann Department of Medical Genetics, University of British Columbia, Vancouver, Canada
  • Gartner, Anton Max Planck Institute for Biochemistry, Martinsried, Germany
  • Müller, Fritz Department of Biology, University of Fribourg, Switzerland
Show more…
    2004
Published in:
  • Molecular and Cellular Biology, 2004, vol. 24, no. 5016-5027
English Bloom's syndrome (BS) is an autosomal-recessive human disorder caused by mutations in the BS RecQ helicase and is associated with loss of genomic integrity and an increased incidence of cancer. We analyzed the mitotic and the meiotic roles of Caenorhabditis elegans him-6, which we show to encode the ortholog of the human BS gene. Mutations in him-6 result in an enhanced irradiation... Show more…
Language
  • English
Identifiers
Classification
Biology
Faculty
Faculté des sciences
Department
Biologie
License
License undefined
Persistent URL
https://folia.unifr.ch/global/documents/299550