Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.
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Lorenz MW
Department of Neurology, Goethe University, Frankfurt am Main, Germany.
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Gao L
MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom.
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Ziegelbauer K
Department of Neurology, Goethe University, Frankfurt am Main, Germany.
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Norata GD
Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy.
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Empana JP
Paris Cardiovascular Research Centre (PARCC), University Paris Descartes, Sorbonne Paris Cité, UMR, Paris, France.
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Schmidtmann I
Institut fuer Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Universitaetsmedizin Mainz, Mainz, Germany.
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Lin HJ
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
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McLachlan S
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
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Bokemark L
Wallenberg Laboratory for Cardiovascular Research, Institution for Medicin, Department for Molecular and Clinical Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
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Ronkainen K
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
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Amato M
Centro Cardiologico Monzino, IRCCS, Milano, Italy.
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Schminke U
Department of Neurology, Greifswald University Clinic, Greifswald, Germany.
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Srinivasan SR
Center for Cardiovascular Health, Department of Epidemiology, Biochemistry, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
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Lind L
Department of Medicine, Uppsala University, Uppsala, Sweden.
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Okazaki S
Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
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Stehouwer CDA
Department of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands.
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Willeit P
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
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Polak JF
Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America.
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Steinmetz H
Department of Neurology, Goethe University, Frankfurt am Main, Germany.
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Sander D
Department of Neurology, Benedictus Hospital Tutzing & Feldafing, Feldafing, Germany.
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Poppert H
Department of Neurology, Technische Universität München, Munich, Germany.
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Desvarieux M
Department of Epidemiology,Mailman School of Public Health,Columbia University, New York, United States of America.
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Ikram MA
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Johnsen SH
Department of Clinical Medicine, Uit The Arctic University of Norway, Tromsø, Norway.
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Staub D
Department of Angiology, University Hospital Basel, Basel, Switzerland.
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Sirtori CR
Center of Dyslipidemias, Niguarda Ca' Granda Hospital, Milano, Italy.
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Iglseder B
Parcelsus Medical University, Salzburg, Austria.
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Beloqui O
Department of Internal Medicine, University Clinic of Navarra, Navarra, Spain.
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Engström G
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
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Friera A
Radiology Department, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
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Rozza F
School of Medicine, Federico II University, Naples, Italy.
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Xie W
Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
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Parraga G
Robarts Research Institute, Western University, London, Ontario, Canada.
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Grigore L
Centro Sisa per lo Studio della Aterosclerosi, Bassini Hospital, Cinisello Balsamo, Italy.
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Plichart M
Assistance Publique, Hôpitaux de Paris, Hôpital Broca, Paris, France.
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Blankenberg S
2nd Department of Medicine, Johannes Gutenberg-Universität, Mainz, Germany.
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Su TC
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
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Schmidt C
Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Gothenburg, Sweden.
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Tuomainen TP
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
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Veglia F
Centro Cardiologico Monzino, IRCCS, Milano, Italy.
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Völzke H
German Center for Cardiovascular Research (DZHK),partner site Greifswald, Greifswald, Germany.
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Nijpels G
Department of General Practice, VU University Medical Center, Amsterdam, the Netherlands.
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Willeit J
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
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Sacco RL
Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
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Franco OH
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
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Uthoff H
Department of Angiology, University Hospital Basel, Basel, Switzerland.
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Hedblad B
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
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Suarez C
Internal Medicine Department, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
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Izzo R
School of Medicine, Federico II University, Naples, Italy.
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Zhao D
Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
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Wannarong T
Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada.
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Catapano A
IRCSS Multimedica, Milan, Italy.
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Ducimetiere P
University Paris_Sud Xi, Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
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Espinola-Klein C
2nd Department of Medicine, Johannes-Gutenberg University, Mainz, Germany.
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Chien KL
Institute of Epidemiology and Preventive Medicine, College of Public Health,National Taiwan University, Taipei, Taiwan.
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Price JF
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
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Bergström G
Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Gothenburg University, Götheborg, Sweden.
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Kauhanen J
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
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Tremoli E
Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy.
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Dörr M
Department B for Internal Medicine, University Medicine Greifswald, Greifswald, Germany.
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Berenson G
Department of Medicine, Pediatrics, Biochemistry, Epidemiology, Tulane University School of Medicine and School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
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Kitagawa K
Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
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Dekker JM
Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
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Kiechl S
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
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Sitzer M
Department of Neuology, Klinikum Herford, Herford, Germany.
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Bickel H
Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.
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Rundek T
Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
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Hofman A
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Mathiesen EB
Department of Clinical Medicine, Uit The Arctic University of Norway, Tromsø, Norway.
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Castelnuovo S
Center of Dyslipidemias, Niguarda Ca' Granda Hospital, Milano, Italy.
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Landecho MF
Department of Internal Medicine, University Clinic of Navarra, Navarra, Spain.
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Rosvall M
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
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Gabriel R
Escuela National de Sanidad, Instituto de Salud Carlos III, Madrid, Spain.
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de Luca N
School of Medicine, Federico II University, Naples, Italy.
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Liu J
Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
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Baldassarre D
Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy.
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Kavousi M
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands.
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de Groot E
Imagelabonline & Cardiovascular, Eindhoven and Lunteren, the Netherlands.
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Bots ML
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
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Yanez DN
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
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Thompson SG
Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
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English
AIMS
Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.
METHODS AND RESULTS
From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C.
CONCLUSIONS
We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.
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Language
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Open access status
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gold
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Identifiers
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Persistent URL
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https://folia.unifr.ch/global/documents/299226
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