A Resting-State Brain Functional Network Study in MDD Based on Minimum Spanning Tree Analysis and the Hierarchical Clustering
- Li, Xiaowei School of Information Science & Engineering, Lanzhou University, Lanzhou, China
- Jing, Zhuang School of Information Science & Engineering, Lanzhou University, Lanzhou, China
- Hu, Bin ORCID School of Information Science & Engineering, Lanzhou University, Lanzhou, China
- Zhu, Jing School of Information Science & Engineering, Lanzhou University, Lanzhou, China
- Zhong, Ning ORCID International WIC Institute, Beijing University of Technology, Beijing, China
- Li, Mi ORCID International WIC Institute, Beijing University of Technology, Beijing, China
- Ding, Zhijie The Third People’s Hospital of Tianshui City, Tianshui, China
- Yang, Jing Lanzhou University Second Hospital, Lanzhou, China
- Zhang, Lan Lanzhou University Second Hospital, Lanzhou, China
- Feng, Lei Beijing Anding Hospital of Capital Medical University, Beijing, China
- Majoe, Dennis Computer Systems Institute, ETH Zürich, Zürich, Switzerland
Published in:
- Complexity. - Hindawi Limited. - 2017, vol. 2017, p. 1-11
English
A large number of studies demonstrated that major depressive disorder (MDD) is characterized by the alterations in brain functional connections which is also identifiable during the brain’s “resting-state.” But, in the present study, the approach of constructing functional connectivity is often biased by the choice of the threshold. Besides, more attention was paid to the number and length of links in brain networks, and the clustering partitioning of nodes was unclear. Therefore, minimum spanning tree (MST) analysis and the hierarchical clustering were first used for the depression disease in this study. Resting-state electroencephalogram (EEG) sources were assessed from 15 healthy and 23 major depressive subjects. Then the coherence, MST, and the hierarchical clustering were obtained. In the theta band, coherence analysis showed that the EEG coherence of the MDD patients was significantly higher than that of the healthy controls especially in the left temporal region. The MST results indicated the higher leaf fraction in the depressed group. Compared with the normal group, the major depressive patients lost clustering in frontal regions. Our findings suggested that there was a stronger brain interaction in the MDD group and a left-right functional imbalance in the frontal regions for MDD controls.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1155/2017/9514369
- ISSN 1076-2787
- Persistent URL
- https://folia.unifr.ch/global/documents/295349
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