Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography.

• Tom S From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
• Frayne M From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
• Manske SL From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
• Burghardt AJ From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
• Stok KS From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
• Boyd SK From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary.
• Barnabe C From the Department of Medicine, Faculty of Medicine, University of Toronto, Toronto; Department of Mechanical Engineering, University of Waterloo, Waterloo, Ontario; McCaig Institute for Bone and Joint Health, University of Calgary; the departments of Radiology and Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA; Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; Schulich School of Engineering, University of Calgary; Faculty of Kinesiology, and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.S. Tom, MD, Rheumatology Resident, Department of Medicine, Faculty of Medicine, University of Toronto; M. Frayne, Bachelor of Applied Science Student, Mechanical Engineering, Department of Mechanical Engineering, University of Waterloo, and McCaig Institute for Bone and Joint Health, University of Calgary; S.L. Manske, PhD, Research Associate, McCaig Institute for Bone and Joint Health, University of Calgary, and Department of Radiology, Cumming School of Medicine, University of Calgary; A.J. Burghardt, BS, Research Specialist, Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco; K.S. Stok, PhD, Senior Research Associate, Institute for Biomechanics, ETH Zurich; S.K. Boyd, PhD, Professor, Department of Radiology, McCaig Institute for Bone and Joint Health, and Department of Radiology, Cumming School of Medicine, and Schulich School of Engineering, and Faculty of Kinesiology, University of Calgary; C. Barnabe, MD, MSc, Assistant Professor, Department of Medicine and Department of Community Health Sciences, and McCaig Institute for Bone and Joint Health, University of Calgary. ccbarnab@ucalgary.ca.

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HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY

JOINT SPACE NARROWING

OSTEOARTHRITIS

RHEUMATOID ARTHRITIS

Humans

Metacarpophalangeal Joint

Range of Motion, Articular

Reproducibility of Results

Tomography, X-Ray Computed