Dried Blood Spot Thyroglobulin as a Biomarker of Iodine Status in Pregnant Women.
- Stinca S Human Nutrition Laboratory, Institute of Food Nutrition and Health, ETH Zurich, Zurich 8092, Switzerland.
- Andersson M Human Nutrition Laboratory, Institute of Food Nutrition and Health, ETH Zurich, Zurich 8092, Switzerland.
- Weibel S Human Nutrition Laboratory, Institute of Food Nutrition and Health, ETH Zurich, Zurich 8092, Switzerland.
- Herter-Aeberli I Human Nutrition Laboratory, Institute of Food Nutrition and Health, ETH Zurich, Zurich 8092, Switzerland.
- Fingerhut R Swiss Newborn Screening Laboratory, Children's Research Center (CRC), University Children's Hospital of Zurich, Zurich 8032, Switzerland.
- Gowachirapant S Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand.
- Hess SY Department of Nutrition, University of California, Davis, Davis, California 95616.
- Jaiswal N St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore 560034, India.
- Jukic T Department of Oncology and Nuclear Medicine, University of Zagreb School of Medicine, Sisters of Charity University Hospital Centre, Zagreb 10,000, Croatia.
- Kusic Z Department of Oncology and Nuclear Medicine, University of Zagreb School of Medicine, Sisters of Charity University Hospital Centre, Zagreb 10,000, Croatia.
- Mabapa NS Department of Nutrition, University of Venda, Thohoyandou 0950, South Africa.
- Nepal AK Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Ghopa, Dharan 56700, Nepal.
- San Luis TO Iodine Global Network (IGN), Manila 1102, Philippines; and.
- Zhen JQ Shanxi Institute for Endemic Disease Prevention and Treatment, LinFen 041000, China.
- Zimmermann MB Human Nutrition Laboratory, Institute of Food Nutrition and Health, ETH Zurich, Zurich 8092, Switzerland.
- 2016-10-13
Published in:
- The Journal of clinical endocrinology and metabolism. - 2017
Adult
Autoantibodies
Biomarkers
Cross-Sectional Studies
Dried Blood Spot Testing
Female
Follow-Up Studies
Humans
Iodine
Pregnancy
Pregnancy Trimesters
Prognosis
Reference Values
Thyroglobulin
Young Adult
English
Context
Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies.
Objectives
Our aims were to (1) establish and test a reference range for DBS-Tg in PW; (2) determine whether co-measurement of Tg antibodies (Abs) is necessary to define population iodine status.
Design, Setting, and Participants
Standardized cross-sectional studies of 3870 PW from 11 countries. For the DBS-Tg reference range, we included TgAb-negative PW (n = 599) from 3 countries with sufficient iodine intake.
Main Outcome Measures
We measured the urinary iodine concentration and DBS thyroid-stimulating hormone, total thyroxin, Tg, and TgAb.
Results
In the reference population, the median DBS-Tg was 9.2 μg/L (95% confidence interval, 8.7 to 9.8 μg/L) and was not significantly different among trimesters. The reference range was 0.3 to 43.5 μg/L. Over a range of iodine intake, the Tg concentrations were U-shaped. Within countries, the median DBS-Tg and the presence of elevated DBS-Tg did not differ significantly between all PW and PW who were TgAb-negative.
Conclusions
A median DBS-Tg of ∼10 μg/L with <3% of values ≥44 μg/L indicated population iodine sufficiency. Concurrent measurement of TgAb did not appear necessary to assess the population iodine status.
Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies.
Objectives
Our aims were to (1) establish and test a reference range for DBS-Tg in PW; (2) determine whether co-measurement of Tg antibodies (Abs) is necessary to define population iodine status.
Design, Setting, and Participants
Standardized cross-sectional studies of 3870 PW from 11 countries. For the DBS-Tg reference range, we included TgAb-negative PW (n = 599) from 3 countries with sufficient iodine intake.
Main Outcome Measures
We measured the urinary iodine concentration and DBS thyroid-stimulating hormone, total thyroxin, Tg, and TgAb.
Results
In the reference population, the median DBS-Tg was 9.2 μg/L (95% confidence interval, 8.7 to 9.8 μg/L) and was not significantly different among trimesters. The reference range was 0.3 to 43.5 μg/L. Over a range of iodine intake, the Tg concentrations were U-shaped. Within countries, the median DBS-Tg and the presence of elevated DBS-Tg did not differ significantly between all PW and PW who were TgAb-negative.
Conclusions
A median DBS-Tg of ∼10 μg/L with <3% of values ≥44 μg/L indicated population iodine sufficiency. Concurrent measurement of TgAb did not appear necessary to assess the population iodine status.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1210/jc.2016-2829
- PMID 27732337
- Persistent URL
- https://folia.unifr.ch/global/documents/291653
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