Journal article
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.
- Brühlmann C Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland.
- Ooms F
- Carrupt PA
- Testa B
- Catto M
- Leonetti F
- Altomare C
- Carotti A
- 2001-09-07
Published in:
- Journal of medicinal chemistry. - 2001
Acetylcholinesterase
Animals
Cholinesterase Inhibitors
Coumarins
Eels
Monoamine Oxidase Inhibitors
Structure-Activity Relationship
English
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3-100 microM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease beta-amyloid deposition.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/jm010894d
- PMID 11543689
- Persistent URL
- https://folia.unifr.ch/global/documents/289329
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