Journal article
Pityriasis rosea is not associated with human herpesvirus 7.
- Kempf W Department of Dermatology, University Hospital, Zurich, Switzerland.
- Adams V
- Kleinhans M
- Burg G
- Panizzon RG
- Campadelli-Fiume G
- Nestle FO
- 1999-09-18
Published in:
- Archives of dermatology. - 1999
Adolescent
Adult
Antigens, Viral
Biopsy
Cross-Sectional Studies
DNA, Viral
Herpesvirus 7, Human
Humans
Middle Aged
Pityriasis Rosea
Retrospective Studies
English
OBJECTIVE
To examine the proposed association between pityriasis rosea and human herpesvirus 7 (HHV-7).
DESIGN
A retrospective cross-sectional survey.
SETTING
University medical center in Switzerland.
PATIENTS
Thirteen patients with pityriasis rosea and 14 persons with normal skin (control subjects).
MAIN OUTCOME MEASURES
Detection of HHV-7-specific DNA sequences and antigen (85-kd phosphoprotein [pp85]) by nested polymerase chain reaction and immunohistochemical analysis, respectively.
RESULTS
Human herpesvirus 7 DNA sequences and expression of the HHV-7-specific immunodominant pp85 antigen were found in 1 (8%) of 13 lesional skin biopsy specimens of pityriasis rosea. The prevalence of HHV-7 DNA sequences and antigens is even slightly lower in lesional skin of patients with pityriasis rosea than in clinically and morphologically normal skin of 14 control persons, in 2 of whom (14%) HHV-7 DNA sequences and antigens could be detected.
CONCLUSION
The low detection rate of HHV-7 DNA sequences and antigens argues strongly against a causative role for HHV-7 in the pathogenesis of pityriasis rosea.
To examine the proposed association between pityriasis rosea and human herpesvirus 7 (HHV-7).
DESIGN
A retrospective cross-sectional survey.
SETTING
University medical center in Switzerland.
PATIENTS
Thirteen patients with pityriasis rosea and 14 persons with normal skin (control subjects).
MAIN OUTCOME MEASURES
Detection of HHV-7-specific DNA sequences and antigen (85-kd phosphoprotein [pp85]) by nested polymerase chain reaction and immunohistochemical analysis, respectively.
RESULTS
Human herpesvirus 7 DNA sequences and expression of the HHV-7-specific immunodominant pp85 antigen were found in 1 (8%) of 13 lesional skin biopsy specimens of pityriasis rosea. The prevalence of HHV-7 DNA sequences and antigens is even slightly lower in lesional skin of patients with pityriasis rosea than in clinically and morphologically normal skin of 14 control persons, in 2 of whom (14%) HHV-7 DNA sequences and antigens could be detected.
CONCLUSION
The low detection rate of HHV-7 DNA sequences and antigens argues strongly against a causative role for HHV-7 in the pathogenesis of pityriasis rosea.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1001/archderm.135.9.1070
- PMID 10490111
- Persistent URL
- https://folia.unifr.ch/global/documents/286823
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