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Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
Journal article

Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

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  • 2004-12-31
Published in:
  • The New England journal of medicine. - 2004
Analgesics, Opioid
Antitussive Agents
Codeine
Cough
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Dextromethorphan
Genotype
Humans
Lung Diseases, Fungal
Male
Methylation
Middle Aged
Phenotype
Pneumonia
English Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a cough associated with bilateral pneumonia. Codeine is bioactivated by CYP2D6 into morphine, which then undergoes further glucuronidation. CYP2D6 genotyping showed that the patient had three or more functional alleles, a finding consistent with ultrarapid metabolism of codeine. We attribute the toxicity to this genotype, in combination with inhibition of CYP3A4 activity by other medications and a transient reduction in renal function.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/285447
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