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[Angiogenesis and bladder cancer: trendy prognostic factor or new therapeutic target?].
Journal article

[Angiogenesis and bladder cancer: trendy prognostic factor or new therapeutic target?].

  • 2002-08-07
Published in:
  • Annales d'urologie. - 2002
Angiogenesis Inducing Agents
Angiogenesis Inhibitors
Animals
Antineoplastic Agents
Carcinoma, Transitional Cell
Clinical Trials as Topic
Collagen
Endostatins
Fibroblast Growth Factor 2
Humans
Lymphatic Metastasis
Mice
Mice, Nude
Neoplasm Transplantation
Neovascularization, Pathologic
Peptide Fragments
Phenotype
Prognosis
Rabbits
Research
Retrospective Studies
Risk Factors
Thrombospondin 1
Urinary Bladder Neoplasms
English Tumor-associated angiogenesis is emerging as an important prognostic factor and represents a hopeful potential therapeutic target for the cancer treatment. Bladder tumors, as all solid tumors, require an active angiogenesis to support their growth and progression. The angiogenic phenotype observed within a tumor is determined in large part by the balance between stimulatory and inhibitory inputs to the endothelial cells. Clinically, the importance of the angiogenic response observed within a tumor should be considered as an independent prognostic factor for superficial as well as invasive bladder tumors. The analysis of the angiogenic response could in the future influence the therapeutic strategy. Angiogenesis also represents a promising new therapeutic target, and is at the moment intensively tested in experimental and clinical trials. In this article, we will first review the mechanism of angiogenesis, and then its implication in bladder cancer, and as a potential therapeutic target.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/282778
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